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Plos One : the Pi3K, Volume 8

By: Gayle E. Woloschak

Description : The etiology of radiation-induced cardiovascular disease (CVD) after chronic exposure to low doses of ionizing radiation is only marginally understood. We have previously shown that a chronic low-dose rate exposure (4.1 mGy/h) causes human umbilical vein endothelial cells (HUVECs) to prematurely senesce. We now show that a dose rate of 2.4 mGy/h is also able to trigger premature senescence in HUVECs, primarily indicated by a loss of growth potential and the...

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Plos One : Overexpression of E2F1 Promotes Tumor Malignancy and Co...

By: Hiromu Suzuki

Description : Overexpression of E2F1 may be a key event in the local and vascular infiltration of ccRCC indicated by the activation of matrix metalloproteinase (MMP) 2 and MMP9. These findings highlighted the implication of E2F1’s function in the metastatic process. Furthermore, the clinical relevance of E2F1 in ccRCC pointed to a potential new therapeutic target

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Plos One : a Model of Filiform Hair Distribution on the Cricket Ce...

By: Vincent Laudet

Description : Crickets and other orthopteran insects sense air currents with a pair of abdominal appendages resembling antennae, called cerci. Each cercus in the common house cricket Acheta domesticus is covered with between 500 to 750 filiform mechanosensory hairs. The distribution of the hairs on the cerci, as well as the global patterns of their movement axes, are very stereotypical across different animals in this species, and the development of this system has been ...

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Plos One : Cord Blood Lin2Cd452 Embryonic-like Stem Cells Are a He...

By: Zoran Ivanovic

Description : Human umbilical cord blood (hUCB) has been proposed to contain not only haematopoietic stem cells, but also a rare pluripotent embryonic-like stem cell (ELSc) population that is negative for hematopoietic markers (Lin2CD452) and expresses markers typical of pluripotent cells. The aim of this work was to isolate, characterise and expand this ELSc fraction from hUCB, as it may provide a valuable cell source for regenerative medicine applications. We found tha...

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Plos One : Isn’t it Ironic Neural Correlates of Irony Comprehensio...

By: Yu-feng Zang

Description : Ironic remarks are frequent in everyday language and represent an important form of social cognition. Increasing evidence indicates a deficit in comprehension in schizophrenia. Several models for defective comprehension have been proposed, including possible roles of the medial prefrontal lobe, default mode network, inferior frontal gyri, mirror neurons, right cerebral hemisphere and a possible mediating role of schizotypal personality traits. We investigat...

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Plos One : Non-diabetic Hyperglycemia Exacerbates Disease Severity...

By: Petros C. Karakousis

Description : Hyperglycemia, the diagnostic feature of diabetes also occurs in non-diabetics associated with chronic inflammation and systemic insulin resistance. Since the increased risk of active TB in diabetics has been linked to the severity and duration of hyperglycemia, we investigated what effect diet-induced hyperglycemia had on the severity of Mycobacterium tuberculosis (Mtb) infection in non-diabetic guinea pigs. Post-prandial hyperglycemia was induced in guine...

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Plos One : In-depth Analysis of Patient-clinician Cell Phone Commu...

By: James Coyne

Description : The WelTel intervention enabled frequent communication between clinicians and patients during the WelTel Kenya1 trial. Many patients valued the service for the support it provided, with health-related concerns comprising the majority of problems identified by participants. Few sociodemographic characteristics were associated with participant engagement in the intervention.

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Plos One : Clonal Expansion of Both Modern and Ancient Genotypes o...

By: Olivier Neyrolles

Description : We present the first comprehensive analysis of Mycobacterium tuberculosis isolates circulating in the Kaohsiung region of southern Taiwan. The major spoligotypes found in the 224 isolates studied were Beijing lineages (n = 97: 43.3%), EAI lineages (n = 72: 32.1%) and Haarlem lineages (n = 18: 8.0%). By 24 MIRU-VNTR typing, 174 patterns were identified, including 24 clusters of 74 isolates and 150 unique patterns. The combination of spoligotyping and 12-MIRU...

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Plos One : Contemporaneous Trace and Body Fossils from a Late Plei...

By: Richard J. Butler

Description : The co-occurrence of vertebrate trace and body fossils within a single geological formation is rare and the probability of these parallel records being contemporaneous (i.e. on or near the same bedding plane) is extremely low. We report here a late Pleistocene locality from the Victorian Volcanic Plains in south-eastern Australia in which demonstrably contemporaneous, but independently accumulated vertebrate trace and body fossils occur. Bite marks from a v...

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Plos One : Nuclear T-star Protein Expression Correlates with Her2 ...

By: Antimo Migliaccio

Description : T-STAR (testis-signal transduction and activation of RNA) is an RNA binding protein, containing an SH3-binding domain and thus potentially playing a role in integration of cell signaling and RNA metabolism. The specific function of T-STAR is unknown and its implication in cancer is poorly characterized. Expression of T-STAR has been reported in human testis, muscle and brain tissues, and is associated with a growth-inhibitory role in immortalized fibroblast...

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Plos One : in Vivo Knockdown of Tak1 Accelerates Bone Marrow Proli...

By: Rajasingh Johnson

Description : TAK1 (TGF-b Activated Kinase 1) is a MAPK kinase kinase, which activates the p38- and JNK-MAPK and NF-kB pathways downstream of receptors such as Toll-Like-, cytokine- and T-cell and B-cell receptors. Representing such an important node in the pro-inflammatory signal-transduction network, the function of TAK1 has been studied extensively. TAK1 knock-out mice are embryonic lethal, while conditional knock-out mice demonstrated either a pro- or anti-inflammato...

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Plos One : Effect of Socioeconomic Status on Mortality After Bacte...

By: Caroline L. Trotter

Description : Low SES was strongly associated with increased 30-day mortality after bacteremia. Less social support, more pre-existing comorbidity, more substance abuse, and differences in place of acquisition and agent of infection appeared to mediate much of the observed disparities in mortality.

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Plos One : Ldx ; Estimation of Linkage Disequilibrium from High- T...

By: Rongling Wu

Description : High-throughput pooled resequencing offers significant potential for whole genome population sequencing. However, its main drawback is the loss of haplotype information. In order to regain some of this information, we present LDx, a computational tool for estimating linkage disequilibrium (LD) from pooled resequencing data. LDx uses an approximate maximum likelihood approach to estimate LD (r2) between pairs of SNPs that can be observed within and among sin...

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Plos One : Genomic Evaluation of Thermoanaerobacterspp. for the Co...

By: Mickaël Desvaux

Description : The microbial production of ethanol from lignocellulosic biomass is a multi-component process that involves biomass hydrolysis, carbohydrate transport and utilization, and finally, the production of ethanol. Strains of the genus Thermoanaerobacter have been studied for decades due to their innate abilities to produce comparatively high ethanol yields from hemicellulose constituent sugars. However, their inability to hydrolyze cellulose, limits their usefuln...

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Plos One : Starvation-associated Genome Restructuring Can Lead to ...

By: William J. Etges

Description : Knowledge of the mechanisms that lead to reproductive isolation is essential for understanding population structure and speciation. While several models have been advanced to explain post-mating reproductive isolation, experimental data supporting most are indirect. Laboratory investigations of this phenomenon are typically carried out under benign conditions, which result in low rates of genetic change unlikely to initiate reproductive isolation. Previousl...

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Plos One : the Advocacy for Pedestrian Safety Study ; Cluster Rand...

By: K. Robert Hills

Description : This study demonstrates the feasibility of an innovative approach to translational public health by targeting local politicians in a randomised controlled trial. The intervention package was positively viewed and raised interest but changes in interventions were not statistically significance. Longer term supported advocacy may be needed.

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Plos One : Predictive Value of Clinical Judgment of Tumour Progres...

By: John W. Glod

Description : According to this study, the clinical judgment of PD is highly predictive of radiological PD as assessed, for example, by RECIST. Physicians do not overestimate PD occurence. Clinical judgment of PD could be taken into account in the definition of PD.

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Plos One : Face Recognition Using Sparse Representation-based Clas...

By: Vladimir Brusic

Description : The sparse representation-based classification (SRC) has been proven to be a robust face recognition method. However, its computational complexity is very high due to solving a complex l1-minimization problem. To improve the calculation efficiency, we propose a novel face recognition method, called sparse representation-based classification on k-nearest subspace (SRC-KNS). Our method first exploits the distance between the test image and the subspace of eac...

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Plos One : A20 Restricts Wnt Signaling in Intestinal Epithelial Ce...

By: Georgina L. Hold

Description : Colon carcinogenesis consists of a multistep process during which a series of genetic and epigenetic adaptations occur that lead to malignant transformation. Here, we have studied the role of A20 (also known as TNFAIP3), a ubiquitin-editing enzyme that restricts NFkB and cell death signaling, in intestinal homeostasis and tumorigenesis. We have found that A20 expression is consistently reduced in human colonic adenomas than in normal colonic tissues. To fur...

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Plos One : Factors Associated with Condom Use Among Male College S...

By: Hamid Reza Baradaran

Description : Improving attitudes of male students toward contraceptive responsibility, providing proper reproductive health information through mass media and making free condoms and reproductive health counseling available in school may help increase condom use among college students in China.

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