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Plos One : Non-synonymous Polymorphisms in the Fcn1Gene Determine ...

By: Alberico Catapano

Description : Overall, our study interlinks the genotype and phenotype relationship concerning polymorphisms in FCN1 and corresponding concentrations and biological functions of M-ficolin. The elucidations of these associations provide information for future genetic studies in the lectin pathway and complement system.

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Plos One : Prediabetes is Associated with an Increased Risk of Tes...

By: Harpal Singh Randeva

Description : Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and MetS. After adjusting for MetS, the risk equals that of diabetes. Our data suggest that testosterone should be measured routinely in men with prediabetes.

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Plos One : Randomised Clinical Trial Investigating the Specificity...

By: Delia Goletti

Description : C-Tb offers a simple and convenient skin test to diagnose M. tuberculosis infection using a single, universal cutoff unaffected by BCG vaccination.

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Plos One : Taxonomic and Life History Bias in Herbicide Resistant ...

By: Boris Alexander Vinatzer

Description : Evolved herbicide resistance (EHR) is an important agronomic problem and consequently a food security problem, as it jeopardizes herbicide effectiveness and increases the difficulty and cost of weed management. EHR in weeds was first reported in 1970 and the number of cases has accelerated dramatically over the last two decades. Despite 40 years of research on EHR, why some weeds evolve resistance and others do not is poorly understood. Here we ask whether ...

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Plos One : Effects of Dietary Cooked Navy Bean on the Fecal Microb...

By: Baochuan Lin

Description : No negative alterations of microbial populations occurred following cooked navy bean intake in dogs, indicating that bean powders may be a viable protein and fiber source for commercial pet foods. The highly variable microbial populations observed in these healthy adult pet dogs at baseline is one potential reason for the difficulty to detect alterations in microbial populations following dietary changes. Given the potential physiological benefits of bean i...

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Plos One : Low Voltage Activation of Kca1.1 Current by Cav3- Kca1....

By: Stuart E. Dryer

Description : Calcium-activated potassium channels of the KCa1.1 class are known to regulate repolarization of action potential discharge through a molecular association with high voltage-activated calcium channels. The current study examined the potential for low voltage-activated Cav3 (T-type) calcium channels to interact with KCa1.1 when expressed in tsA-201 cells and in rat medial vestibular neurons (MVN) in vitro. Expression of the channel a-subunits alone in tsA-20...

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Plos One : Inflammatory Cytokines and Survival Factors from Serum ...

By: Daniel Sanchis

Description : Tumor necrosis factor-like weak inducer of apoptosis (TWEAK, TNFSF12) is a member of the tumor necrosis factor superfamily. TWEAK activates the Fn14 receptor, and may regulate cell death, survival and proliferation in tumor cells. However, there is little information on the function and regulation of this system in prostate cancer. Fn14 expression and TWEAK actions were studied in two human prostate cancer cell lines, the androgen-independent PC-3 cell line...

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Plos One : Copper Oxide Nanoparticles Induced Mitochondria Mediate...

By: Aditya Bhushan Pant

Description : Copper oxide nanoparticles (CuO NPs) are heavily utilized in semiconductor devices, gas sensor, batteries, solar energy converter, microelectronics and heat transfer fluids. It has been reported that liver is one of the target organs for nanoparticles after they gain entry into the body through any of the possible routes. Recent studies have shown cytotoxic response of CuO NPs in liver cells. However, the underlying mechanism of apoptosis in liver cells due...

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Plos One : a Novel Approach to Enhancing Ganoderic Acid Production...

By: Jae-hyuk Yu

Description : Ganoderma lucidum is one of most widely used herbal medicine and functional food in Asia, and ganoderic acids (GAs) are its active ingredients. Regulation of GA biosynthesis and enhancing GA production are critical to using G. lucidum as a medicine. However, regulation of GA biosynthesis by various signaling remains poorly understood. This study investigated the role of apoptosis signaling on GA biosynthesis and presented a novel approach, namely apoptosis ...

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Plos One : Varicella-zoster Viruses Associated with Post-herpetic ...

By: Joseph Charles Glorioso

Description : Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella- Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates induce changes in sodium ion channel currents known to be associated with neuropathic pain. Twenty VZV isolates were studied blind from 11 PHN and 9 non-PHN subjects. Viruses were propagated in the MeWo cell lin...

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Plos One : Hiv-1 Genetic Diversity and Transmitted Drug Resistance...

By: Luis Menéndez-arias

Description : HIV-1 Genetic Diversity and Transmitted Drug Resistance Mutations among Patients from the North, Central and South Regions of Angola

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Plos One : the Predictive Nature of Pseudoneglect for Visual Negle...

By: Angela Sirigu

Description : Following parietal damage most patients with visual neglect bisect horizontal lines significantly away from the true centre. Neurologically intact individuals also misbisect lines: a phenomenon referred to as ‘pseudoneglect’. In this study we examined the relationship between neglect and pseudoneglect by testing how patterns of pre-existing visuospatial asymmetry predict asymmetry caused by parietal interference. Twenty-four participants completed line bise...

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Plos One : Continuity of Visual and Auditory Rhythms Influences Se...

By: Ramesh Balasubramaniam

Description : People often coordinate their movement with visual and auditory environmental rhythms. Previous research showed better performances when coordinating with auditory compared to visual stimuli, and with bimodal compared to unimodal stimuli. However, these results have been demonstrated with discrete rhythms and it is possible that such effects depend on the continuity of the stimulus rhythms (i.e., whether they are discrete or continuous). The aim of the curr...

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Plos One : Ferristatin II Promotes Degradation of Transferrin Rece...

By: Makoto Kanzaki

Description : Previous studies have shown that the small molecule iron transport inhibitor ferristatin (NSC30611) acts by down-regulating transferrin receptor-1 (TfR1) via receptor degradation. In this investigation, we show that another small molecule, ferristatin II (NSC8679), acts in a similar manner to degrade the receptor through a nystatin-sensitive lipid raft pathway. Structural domains of the receptor necessary for interactions with the clathrin pathway do not ap...

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Plos One : Regulatory Cd4+foxp3+ T Cells Control the Severity of A...

By: R. Lee Mosley

Description : Constitutive Foxp3+ Treg can control the symptomatic phase of mast cell and IgE-dependent anaphylaxis in mice. This might open up new therapeutic avenues using constitutive rather than Ag-specific Treg for inducing tolerance in allergic patients.

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Plos One : Time to Pregnancy ; a Computational Method for Using th...

By: Fabio Rapallo

Description : An important problem in reproductive medicine is deciding when people who have failed to become pregnant without medical assistance should begin investigation and treatment. This study describes a computational approach to determining what can be deduced about a couple’s future chances of pregnancy from the number of menstrual cycles over which they have been trying to conceive. The starting point is that a couple’s fertility is inherently uncertain. This u...

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Plos One : Joint Association of Sitting Time and Physical Activity...

By: Antony Bayer

Description : In joint analyses of sitting time and physical activity, higher sitting time and insufficient physical activity were deleteriously associated with odds for metabolic risk factors in middle-aged Malay men and women

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Plos One : Sub-diffraction Nano Manipulation Using Sted Afm, Volume 8

By: Giuseppe Chirico

Description : In the last two decades, nano manipulation has been recognized as a potential tool of scientific interest especially in nanotechnology and nano-robotics. Contemporary optical microscopy (super resolution) techniques have also reached the nanometer scale resolution to visualize this and hence a combination of super resolution aided nano manipulation ineluctably gives a new perspective to the scenario. Here we demonstrate how specificity and rapid determinati...

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Plos One : Barnacle Geese Achieve Significant Energetic Savings by...

By: Lewis George Halsey

Description : Here we report the resting metabolic rate in barnacle geese (Branta leucopsis) and provide evidence for the significant energetic effect of posture. Under laboratory conditions flow-through respirometry together with synchronous recording of behaviour enabled a calculation of how metabolic rate varies with posture. Our principal finding is that standing bipedally incurs a 25% increase in metabolic rate compared to birds sitting on the ground. In addition to...

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Plos One : Mitochondrial Uptake of Thiamin Pyrophosphate ; Physiol...

By: James F. Collins

Description : Mammalian cells obtain vitamin B1 (thiamin) from their surrounding environment and convert it to thiamin pyrophosphate (TPP) in the cytoplasm. Most of TPP is then transported into the mitochondria via a carrier-mediated process that involves the mitochondrial thiamin pyrophosphate transporter (MTPPT). Knowledge about the physiological parameters of the MTPP-mediated uptake process, MTPPT targeting and the impact of clinical mutations in MTPPT in patients wi...

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