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Plos One : Complete Genome Sequences of New Xenotropic Murine Leuk...

By: Man-seong Park

Description : Approximately 10% of the mouse genome is constituted by endogenous retroviruses (ERVs), and a number of mouse ERVs remain active. Many copies of endogenous murine leukemia viruses (MuLVs) are detected in the genomes of inbred mouse strains. Some of these MuLVs are transcriptionally active or produce infectious virus particles. Previously, we identified partial env sequences of new xenotropic MuLVs (X-MuLVs) from a senescence-accelerated mouse (SAM) strain. ...

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Plos One : Potentiation of Scutellarinon Human Tongue Carcinoma Xe...

By: W. Todd Miller

Description : Scutellarin 7-O-β-D-glucuronide (scutellarin) has shown great potential as a chemotherapeutic agent for cancer treatment, but only at high dosage. Here we investigate the possibility of using low intensity ultrasound to reduce the scutellarin dosage. Ultrasound intensities of 1.0 W/cm2 and 0.05 W/cm2 were used for in vivo and in vitro experiments, respectively, and a very low dosage of scutellarin (15 nM) was used. Tumor-bearing Balb/c mice and SAS human-to...

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Plos One : Meta-analyses of 8 Polymorphisms Associated with the Ri...

By: Gianluigi Forloni

Description : Our results showed that A2M V1000I polymorphism in German, Korean, Chinese, Spanish, Italian and Polish populations, rs90883 of ABCA2 gene in French, American, Swiss, Greek and Japanese populations, 2384G .A of CHAT gene in British and Korean populations and LPL Ser447Ter in the Northern-American population were associated with the risk of AD

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Plos One : MacRophages, Nitric Oxide and Micrornas Are Associated ...

By: Benoit Foligne

Description : Senescence was observed in IBD with senescence-associated b-galactosidase and HP1c. Macrophages were associated with senescence and DDR in UC, and in vitro experiments with primary human cells showed that macrophages induce senescence, partly through NON, and that NON can induce DDR associated with senescence. Future experiments will investigate the role of NON and miR-21 in senescence. This is the first study to implicate macrophages and nitrosative stress...

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Plos One : Myasthenia Gravis ; Analysis of Serum Autoantibody Reac...

By: Martin Stangel

Description : Seroreactivity profiles of patients with myasthenia gravis detected by a customized protein macroarray did not allow discrimination from healthy controls, compatible with the notion that the autoantibody response in myasthenia gravis is highly focussed against the acetylcholine receptor.

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Plos One : the Dental Plaque Microbiome in Health and Disease, Vol...

By: Sarah K. Highlander

Description : Dental decay is one of the most prevalent chronic diseases worldwide. A variety of factors, including microbial, genetic, immunological, behavioral and environmental, interact to contribute to dental caries onset and development. Previous studies focused on the microbial basis for dental caries have identified species associated with both dental health and disease. The purpose of the current study was to improve our knowledge of the microbial species involv...

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Plos One : Joint Modeling of Multiple Social Networks to Elucidate...

By: Renaud Lambiotte

Description : In a complex behavioral system, such as an animal society, the dynamics of the system as a whole represent the synergistic interaction among multiple aspects of the society. We constructed multiple single-behavior social networks for the purpose of approximating from multiple aspects a single complex behavioral system of interest : rhesus macaque society. Instead of analyzing these networks individually, we describe a new method for jointly analyzing them i...

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Plos One : Noise-induced Tinnitus Using Individualized Gap Detecti...

By: Manuel S. Malmierca

Description : Tinnitus has a complex etiology that involves auditory and non-auditory factors and may be accompanied by hyperacusis, anxiety and cognitive changes. Thus far, investigations of the interrelationship between tinnitus and auditory and nonauditory impairment have yielded conflicting results. To further address this issue, we noise exposed rats and assessed them for tinnitus using a gap detection behavioral paradigm combined with statistically-driven analysis ...

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Plos One : Ste20, Volume 8

By: Shumin Duan

Description : The intracellular concentration of chloride ([Cl-]i) determines the strength and polarity of GABA neurotransmission. STE20/SPS1-related proline/alanine-rich kinase (SPAK) is known as an indirect regulator of [Cl-]i for its activation of Na-K-2 Cl-co-transporters (NKCC) and inhibition of K-Cl-co-transporters (KCC) in many organs. NKCC1 or KCC2 expression changes have been demonstrated previously in the hippocampal neurons of mice with pilocarpineinduced stat...

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Plos One : Clinical Relevance of Loss of 11P15 in Primary and Meta...

By: Sharon A. Glynn

Description : The occurrence of brain metastases among breast cancer patients is currently rising with approximately 20–25% incidence rates, underlining the importance of the identification of new therapeutic and prognostic markers. We have previously screened for new markers for brain metastasis by array CGH. We found that loss of 11p15 is common among these patients. In this study, we investigated the clinical significance of loss of 11p15 in primary breast cancer (BC)...

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Plos One : Microrna Mir-29C Down-regulation Leading to De-repressi...

By: Thiruma V. Arumugam

Description : Recent studies showed that stroke extensively alters cerebral microRNA (miRNA) expression profiles and several miRNAs play a role in mediating ischemic pathophysiology. We currently evaluated the significance of miR-29c, a highly expressed miRNA in rodent brain that was significantly down-regulated after focal ischemia in adult rats as well as after oxygenglucose deprivation in PC12 cells. Bioinformatics indicated that DNA methyltransferase 3a (DNMT3a) is a...

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Plos One : Ivermectin Inhibits Growth of Chlamydia Trachomatis in ...

By: Jean Kanellopoulos

Description : Ivermectin is currently approved for treatment of both clinical and veterinary infections by nematodes, including Onchocerca cervicalis in horses and Onchocerca volvulus in humans. However, ivermectin has never been shown to be effective against bacterial pathogens. Here we show that ivermectin also inhibits infection of epithelial cells by the bacterial pathogen, Chlamydia trachomatis, at doses that could be envisioned clinically for sexually-transmitted o...

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Plos One : Effectiveness of Hiv Risk Reduction Interventions Among...

By: Julian W. Tang

Description : On aggregate, HIV risk reduction interventions were effective in reducing risky behaviors and improving knowledge and attitudes among Chinese MSM, but were not associated with a change in the prevalence of HIV and syphilis. Future studies should use incidence as definitive study outcome.

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Plos One : a Differential Effect of Indian Ocean Dipole and El Nin...

By: Dongsheng Zhou

Description : Our results call for the consideration of non-stationary, possibly non-linear, patterns of association between cholera hospitalizations and climatic factors in cholera epidemic early warning systems.

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Plos One : Evaluation of a Continuous Indicator for Syndromic Surv...

By: Yung-fu Chang

Description : Two vector borne diseases, caused by the Bluetongue and Schmallenberg viruses respectively, have emerged in the European ruminant populations since 2006. Several diseases are transmitted by the same vectors and could emerge in the future. Syndromic surveillance, which consists in the routine monitoring of indicators for the detection of adverse health events, may allow an early detection. Milk yield is routinely measured in a large proportion of dairy herds...

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Plos One : Function of Mouse Embryonic Stem Cell-derived Supportin...

By: Irina Kerkis

Description : The sphere cells in stage 4 are more committed to developing into neural progenitors than monolayer cells. Interaction between the monolayer cells and sphere cells is important in the development of stage 4 cell characteristics.

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Plos One : Discovery and Validation of Dna Hypomethylation Biomark...

By: William B. Coleman

Description : Poor prognosis of hepatocellular carcinoma (HCC) associated with late diagnosis necessitates the development of early diagnostic biomarkers. We have previously delineated the landscape of DNA methylation in HCC patients unraveling the importance of promoter hypomethylation in activation of cancer- and metastasis-driving genes. The purpose of the present study was to test the feasibility that genes that are hypomethylated in HCC could serve as candidate diag...

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Plos One : Effectiveness of Zinc Supplementation to Full Term Norm...

By: Li-min Huang

Description : The study was aimed to test whether zinc supplementation, if initiated early, can prevent stunting and promote optimum body composition in full term infants. For this, full term pregnant women from low income urban community were enrolled and were followed-up for 24 months postpartum. Body mass index (BMI) was calculated from maternal weight and height that were collected one month after delivery. Infants’ weight, and length, head, chest and mid upper arm c...

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Plos One : Separating Drought Effects from Roof Artifacts on Ecosy...

By: Kurt O. Reinhart

Description : 1 : Given the predictions of increased drought probabilities under various climate change scenarios, there have been numerous experimental field studies simulating drought using transparent roofs in different ecosystems and regions. Such roofs may, however, have unknown side effects, called artifacts, on the measured variables potentially confounding the experimental results. A roofed control allows the quantification of potential artifacts, which is lackin...

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Plos One : Inhibition of Aberrant Circulating Tfh Cell Proportions...

By: Gernot Zissel

Description : We demonstrated that elevated circulating Tfh cell proportions in SLE patients correlated with their disease activities, and circulating levels of plasma cells and ANA. Corticosteroids treatment down-regulated aberrant circulating Tfh cell proportions both in vivo and in vitro, making Tfh cells a new treatment target for SLE patients.

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