World Library  


 
  • Cover Image

Plos One : Cd133 Expression and the Prognosis of Colorectal Cancer...

By: Hiromu Suzuki

Description : Our meta-analysis results suggest that CD133 is an efficient prognostic factor in CRC. Higher CD133 expression is significantly associated with poorer clinical outcome and some clinicopathological factors such as T category, N category and vascular invasion in CRC patients.

Read More
  • Cover Image

Plos One : Evaluating the Effectiveness of France’s Indoor Smoke- ...

By: Chris Bullen

Description : France implemented a comprehensive smoke-free law in two phases : Phase 1 (February 2007) banned smoking in workplaces, shopping centres, airports, train stations, hospitals, and schools: Phase 2 (January 2008) banned smoking in hospitality venues (bars, restaurants, hotels, casinos, nightclubs). This paper evaluates France’s smoke-free law based on the International Tobacco Control Policy Evaluation Project in France (the ITC France Project), which conduct...

Read More
  • Cover Image

Plos One : Sle Peripheral Blood B Cell, T Cell and Myeloid Cell Tr...

By: Frederic Rieux-laucat

Description : Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterized by defective immune tolerance combined with immune cell hyperactivity resulting in the production of pathogenic autoantibodies. Previous gene expression studies employing whole blood or peripheral blood mononuclear cells (PBMC) have demonstrated that a majority of patients with active disease have increased expression of type I interferon (IFN) inducible transcripts kno...

Read More
  • Cover Image

Plos One : Mir-22 Controls Irf8 Mrna Abundance and Murine Dendriti...

By: Susan Kovats

Description : MicroRNAs (miRNAs) have emerged as critical regulators of many cellular responses, through the action of miRNA-induced silencing complex (miRISC)- or miRNA ribonucleoprotein complex (miRNP)-mediated gene repression. Here we studied the role of miRNAs in the development of dendritic cells (DCs), an important immune cell type that is divided into conventional DC (cDC) and plasmacytoid DC (pDC) subsets. We found that miR-22 was highly expressed in mouse CD11c+...

Read More
  • Cover Image

Plos One : Breast Cancer Cells Induce Osteolytic Bone Lesions in V...

By: Pranela Rameshwar

Description : Bone metastases are severely debilitating and have a significant impact on the quality of life of women with metastatic breast cancer. Treatment options are limited and in order to develop more targeted therapies, improved understanding of the complex mechanisms that lead to bone lesion development are warranted. Interestingly, whilst prostate-derived bone metastases are characterised by mixed or osteoblastic lesions, breast-derived bone metastases are char...

Read More
  • Cover Image

Plos One : Genome-wide Association Study of D-amphetamine Response...

By: Dan E. Arking

Description : Both the subjective response to d-amphetamine and the risk for amphetamine addiction are known to be heritable traits. Because subjective responses to drugs may predict drug addiction, identifying alleles that influence acute response may also provide insight into the genetic risk factors for drug abuse. We performed a Genome Wide Association Study (GWAS) for the subjective responses to amphetamine in 381 non-drug abusing healthy volunteers. Responses to am...

Read More
  • Cover Image

Plos One : Anchoring Ethinylestradiol Induced Gene Expression Chan...

By: Szabolcs Semsey

Description : Environmental estrogens are ubiquitous in the environment and can cause detrimental effects on male reproduction. In fish, a multitude of effects from environmental estrogens have been observed including altered courting behavior and fertility, sex reversal, and gonadal histopathology. However, few studies in fish assess the impacts of estrogenic exposure on a physiological endpoint, such as reproduction, as well as the associated morphologic response and u...

Read More
  • Cover Image

Plos One : Cysteine Depletion Causes Oxidative Stress and Triggers...

By: Lisa A. Morici

Description : Outer membrane vesicles (OMV) contain immunogenic proteins and contribute to in vivo survival and virulence of bacterial pathogens. The first OMV vaccines successfully stopped Neisseria meningitidis serogroup B outbreaks but required detergent-extraction for endotoxin removal. Current vaccines use attenuated endotoxin, to preserve immunological properties and allow a detergent-free process. The preferred process is based on spontaneously released OMV (sOMV)...

Read More
  • Cover Image

Plos One : Different Patterns of Cytokines and Chemokines Combined...

By: Sunil K. Ahuja

Description : For the 41 examined factors, our results indicated that three patterns were closely associated with infection and disease. (1) Significantly elevated plasma levels of IL-2, IP-10, CXCL11 and CXCL12 were present in both patients with tuberculosis and in a sub-group participant with latent tuberculosis infection who showed a higher level of IFN-c producing cells by ELISPOT assay compared with other latently infected individuals. (2) IL-6 and IL-9 were only si...

Read More
  • Cover Image

Plos One : Inhibition of Oxidative Stress-elicited Akt Activation ...

By: Yin Tintut

Description : Emerging evidence suggests that tumor-initiating cells (TICs) are the most malignant cell subpopulation in tumors because of their resistance to chemotherapy or radiation treatment. Targeting TICs may be a key innovation for cancer treatment. In this study, we found that PPARc agonists inhibited the cancer stem cell-like phenotype and attenuated tumor growth of human hepatocellular carcinoma (HCC) cells. Reactive oxygen species (ROS) initiated by NOX2 upreg...

Read More
  • Cover Image

Plos One : G-protein Coupled Receptor 83 Gpr83 Signaling Determine...

By: Roland Seifert

Description : The G-protein coupled receptor 83 (GPR83) is an orphan G-protein coupled receptor for which the natural ligand(s) and signaling pathway(s) remain to be identified. Previous studies suggest a role of GPR83 in the regulation of thermogenesis and the control of circulating adiponectin. The aim of this study was to gain insights into the molecular underpinnings underlying GPR83 signaling. In particular, we aimed to assess the underlying G-protein activated sign...

Read More
  • Cover Image

Plos One : Combined Effect of Ampk, Volume 7

By: Carlo Gaetano

Description : The present investigation was undertaken to test whether exercise training (ET) associated with AMPK/PPAR agonists (EM) would improve skeletal muscle function in mdx mice. These drugs have the potential to improve oxidative metabolism. This is of particular interest because oxidative muscle fibers are less affected in the course of the disease than glycolitic counterparts. Therefore, a cohort of 34 male congenic C57Bl/10J mdx mice included in this study was...

Read More
  • Cover Image

Plos One : Beneficial Effects of Trypsin Inhibitors Derived from a...

By: Henrik Einwaechter

Description : HWTI is a 55-residue protein isolated from the venom of the spider Ornithoctonus huwena. It is a potent trypsin inhibitor and a moderate voltage-gated potassium channel blocker. Here, we designed and expressed two HWTI mutants, HWTI-mut1 and HWTI-mut2, in which the potassium channel inhibitory activity was reduced while the trypsin inhibitory activity of the wild type form (approximately 5 EPU/mg) was retained. Animal studies showed that these mutants were ...

Read More
  • Cover Image

Plos One : a Lactobacillus Rhamnosus Strain Induces a Heme Oxygena...

By: Ciriaco A. Piccirillo

Description : We investigated the consequences of feeding with a Lactobacillus species on the immune environment in GALT, and the role of dendritic cells and heme oxygenase-1 in mediating these responses. Feeding with a specific strain of Lactobacillus rhamnosus induced a significant increase in CD4+CD25+Foxp3+ functional regulatory T cells in GALT. This increase was greatest in the mesenteric lymph nodes and associated with a marked decrease in TNF and IFNc production. ...

Read More
  • Cover Image

Plos One : Capturing the Biofuel Wellhead and Powerhouse ; the Chl...

By: Jonathan H. Badger

Description : Pongamia pinnata (syn. Millettia pinnata) is a novel, fast-growing arboreal legume that bears prolific quantities of oil-rich seeds suitable for the production of biodiesel and aviation biofuel. Here, we have used IlluminaH ‘Second Generation DNA Sequencing (2GS)’ and a new short-read de novo assembler, SaSSY, to assemble and annotate the Pongamia chloroplast (152,968 bp: cpDNA) and mitochondrial (425,718 bp: mtDNA) genomes. We also show that SaSSY can be u...

Read More
  • Cover Image

Plos One : Insulin-receptor Substrate-2 Irs-2 is Required for Main...

By: Magdalena Anita Hennige

Description : Insulin receptor substrate (IRS) proteins play important roles in hepatic nutrient homeostasis. Since glucokinase (GK) and glucokinase regulatory protein (GKRP) function as key glucose sensors, we have investigated the expression of GK and GKRP in liver of Irs-2 deficient mice and Irs2(2/2) mice where Irs2 was reintroduced specifically into pancreatic b-cells [RIP-Irs-2/ IRS-2(2/2)]. We observed that liver GK activity was significantly lower (p,0.0001) in I...

Read More
  • Cover Image

Plos One : Determinants of Serum Concentrations of Lipopolysacchar...

By: Suryaprakash Sambhara

Description : Serum LBP concentrations increased with age. Overweight, obesity, and having metabolic syndrome (particularly, low HDL cholesterol levels) were associated with higher LBP concentrations. These findings are consistent with microbial exposure playing a role in these inflammatory, metabolic abnormalities.

Read More
  • Cover Image

Plos One : Hemispheric Asymmetry for Affective Stimulus Processing...

By: André Aleman

Description : Our data suggests region-specific functional lateralization of emotion processing. Findings show valence asymmetry for prefrontal cortical areas and left-lateralized negative stimulus processing in subcortical areas, in particular, amygdala and uncus.

Read More
  • Cover Image

Plos One : Evolutionary, Molecular and Genetic Analyses of Tic22 H...

By: Andrew Webber

Description : The Tic22 protein was previously identified in pea as a putative component of the chloroplast protein import apparatus. It is a peripheral protein of the inner envelope membrane, residing in the intermembrane space. In Arabidopsis, there are two Tic22 homologues, termed atTic22-III and atTic22-IV, both of which are predicted to localize in chloroplasts. These two proteins defined clades that are conserved in all land plants, which appear to have evolved at ...

Read More
  • Cover Image

Plos One : a Chemically Defined Medium for Rabbit Embryo Cryoprese...

By: Berta Alsina

Description : This study evaluates a new synthetic substitute (CRYO3, Ref. 5617, Stem Alpha, France) for animal-based products in rabbit embryo cryopreservation solutions. This evaluation was performed using two approaches : a thermodynamic approach using differential scanning calorimetry and a biological approach using rabbit embryo slow-freezing. During the experiment, foetal calf serum (FCS) was used as a reference. Because FCS varies widely by supplier, three differe...

Read More
 
1
|
2
|
3
Records: 1 - 20 of 45 - Pages: 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Fair are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.