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Plos One : an Analysis of Diet Quality, How it Controls Fatty Acid...

By: Immo A. Hansen

Description : Direct routing of FAs was evident but there was ubiquitous de-novo synthesis suggesting mosquito larvae are competent generalist feeders capable of survival on diet with varying characteristics. It was concluded that nitrogen availability in the larval diet controlled teneral mosquito size and that teneral CN ratio is a sex- and speciesspecific fixed parameter. This finding has significant implications for overall mosquito competitiveness and environmental management.

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Plos One : Robust Expression and Secretion of Xylanase1 in Chlamyd...

By: John W. Stiller

Description : Microalgae have recently received attention as a potential low-cost host for the production of recombinant proteins and novel metabolites. However, a major obstacle to the development of algae as an industrial platform has been the poor expression of heterologous genes from the nuclear genome. Here we describe a nuclear expression strategy using the footand- mouth-disease-virus 2A self-cleavage peptide to transcriptionally fuse heterologous gene expression ...

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Plos One : Var2Csa Signatures of High Plasmodium Falciparum Parasi...

By: Luzia Helena Carvalho

Description : Plasmodium falciparum infected erythrocytes (IE) accumulate in the placenta through the interaction between Duffybinding like (DBL) domains of parasite-encoded ligand VAR2CSA and chondroitin sulphate-A (CSA) receptor. Polymorphisms in these domains, including DBL2X and DBL3X, may affect their antigenicity or CSA-binding affinity, eventually increasing parasitemia and its adverse effects on pregnancy outcomes. A total of 373 DBL2X and 328 DBL3X sequences wer...

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Plos One : a U-box E3 Ubiquitin Ligase, Pub20, Interacts with the ...

By: Deanna M. Koepp

Description : An Arabidopsis U-box E3 ubiquitin ligase Plant U-box 20 (PUB20: alternatively called AtCMPG1) was identified as a possible interactor of the Arabidopsis G-protein b subunit, AGB1, by yeast two-hybrid screening. A bimolecular fluorescence complementation (BiFC) assay showed that PUB20 interacted with AGB1 in the nuclei and the cytosol. The expression levels of PUB20 and its closest homolog, PUB21 were stable under many conditions. GUS driven by the PUB20 pro...

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Plos One : Mediterranean Style Diet and 12-year Incidence of Cardi...

By: Qi Sun

Description : Better adherence to a Mediterranean style diet was more strongly associated with fatal CVD than with total CVD. Disease specific associations were strongest for incident myocardial infarction, stroke and pulmonary embolism.

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Plos One : Sted Nanoscopy with Time-gated Detection ; Theoretical ...

By: Giuseppe Chirico

Description : In a stimulated emission depletion (STED) microscope the region in which fluorescence markers can emit spontaneously shrinks with continued STED beam action after a singular excitation event. This fact has been recently used to substantially improve the effective spatial resolution in STED nanoscopy using time-gated detection, pulsed excitation and continuous wave (CW) STED beams. We present a theoretical framework and experimental data that characterize th...

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Plos One : Measuring Visual Field Progression in the Central 10 De...

By: Keisuke Mori

Description : Deriving 10-2 VF MD values from 24-2 VFs improves the prediction accuracy of progression. This approach will help clinicians to predict patients’ visual function in the parafoveal area

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Plos One : Uniparental Markers in Italy Reveal a Sex-biased Geneti...

By: David Caramelli

Description : Located in the center of the Mediterranean landscape and with an extensive coastal line, the territory of what is today Italy has played an important role in the history of human settlements and movements of Southern Europe and the Mediterranean Basin. Populated since Paleolithic times, the complexity of human movements during the Neolithic, the Metal Ages and the most recent history of the two last millennia (involving the overlapping of different cultural...

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Plos One : Prediction Beyond the Borders ; Erp Indices of Boundary...

By: Annette Sterr

Description : Boundary extension (BE) is a rapidly occurring memory error in which participants incorrectly remember having seen beyond the boundaries of a view. However, behavioral data has provided no insight into how quickly after the onset of a test picture the effect is detected. To determine the time course of BE from neural responses we conducted a BE experiment while recording EEG. We exploited a diagnostic response asymmetry to mismatched views (a closer and wid...

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Plos One : Fission Yeast Nod1 is a Component of Cortical Nodes Inv...

By: Simon Whitehall

Description : Most cells enter mitosis once they have reached a defined size. In the fission yeast Schizosaccharomyces pombe, mitotic entry is orchestrated by a geometry-sensing mechanism that involves the Cdk1/Cdc2-inhibiting Wee1 kinase. The factors upstream of Wee1 gather together in interphase to form a characteristic medial and cortical belt of nodes. Nodes are also considered to be precursors of the cytokinesis contractile actomyosin ring (CAR). Here we describe a ...

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Plos One : Robust and Highly-efficient Differentiation of Function...

By: Katriina Aalto-setala

Description : Monocytic lineage cells (monocytes, macrophages and dendritic cells) play important roles in immune responses and are involved in various pathological conditions. The development of monocytic cells from human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) is of particular interest because it provides an unlimited cell source for clinical application and basic research on disease pathology. Although the methods for monocytic cell diff...

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Plos One : Evidence That Head and Body Lice on Homeless Persons Ha...

By: Wenjun Li

Description : Human head lice and body lice are morphologically and biologically similar but have distinct ecologies. They were shown to have almost the same basic genetic content (one gene is absent in head lice), but differentially express certain genes, presumably responsible for the vector competence. They are now believed to be ecotypes of the same species (Pediculus humanus) and based on mitochondrial studies, body lice have been included with head lice in one of t...

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Plos One : Who Starts Factors Associated with Starting Antiretrovi...

By: Sarah Pett

Description : Length of the pre-ART period is the most significant predictor of starting ART among eligible patients. Better understanding of motivation for retention in pre-ART care may reduce attrition along the treatment cascade.

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Plos One : Transcriptome and Proteome Data Reveal Candidate Genes ...

By: Hidenori Sassa

Description : Our comprehensive data set generated by combining transcriptome and proteome technologies allowed identification of candidate genes for pollinator attraction and reproductive isolation among sexually deceptive orchids. This includes genes for hydrocarbon and anthocyanin biosynthesis and regulation, and the development of floral morphology. These data will serve as an invaluable resource for research in orchid floral biology, enabling studies into the molecu...

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Plos One : Meta-analysis of Gadoxetic Acid Disodium Gd-eobdtpa- En...

By: Xiaoyuan Chen

Description : MR imaging with Gd-EOB-DTPA is a reliable, non-invasive, and no-radiation-exposure imaging modality with a high sensitivity and specificity for detection of liver metastases. Nonetheless, it should be applied cautiously, and large scale, well-designed trials are necessary to assess its clinical value.

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Plos One : Integrase-mediated Recombination of the Veb1 Gene Casse...

By: Sergey Korolev

Description : The veb1 gene cassette encodes the extended spectrum b-lactamase, VEB-1 that is increasingly isolated from worldwide Gram-negative rods. Veb1 is commonly inserted into the variable region of different class 1 integrons in which it is always associated with a downstream-located aadB gene cassette encoding an aminoglycoside adenylyltransferase. In Pseudomonas aeruginosa, the majority of veb1-containing integrons also carry an insertion sequence, IS1999 that i...

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Plos One : High and Low Protein ; Carbohydrate Dietary Ratios Duri...

By: Raul M. Luque

Description : Imbalanced maternal nutrition during gestation can cause alterations of the hypothalamic-pituitary-adrenal (HPA) system in offspring. The present study investigated the effects of maternal low- and high-protein diets during gestation in pigs on the maternal-fetal HPA regulation and expression of the glucocorticoid receptor (GR), mineralocorticoid receptor (MR), 11bhydroxysteroid dehydrogenase 1 and 2 (11b-HSD1 and 11b-HSD2) and c-fos mRNAs in the placenta a...

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Plos One : Medium-throughput Processing of Whole Mount in Situ Hyb...

By: Alistair P. McGregor

Description : Understanding the function and evolution of developmental regulatory networks requires the characterisation and quantification of spatio-temporal gene expression patterns across a range of systems and species. However, most highthroughput methods to measure the dynamics of gene expression do not preserve the detailed spatial information needed in this context. For this reason, quantification methods based on image bioinformatics have become increasingly imp...

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Plos One : the Proliferation Index of Specific Bone Marrow Cell Co...

By: Alfons Navarro

Description : Myelodysplastic syndromes (MDS) are clonal stem cell disorders which frequently show a hypercellular dysplastic bone marrow (BM) associated with inefficient hematopoiesis and peripheral cytopenias due to increased apoptosis and maturation blockades. Currently, little is known about the role of cell proliferation in compensating for the BM failure syndrome and in determining patient outcome. Here, we analyzed the proliferation index (PI) of different compart...

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Plos One : Tyrosine Hydroxylase Phosphorylation in Catecholaminerg...

By: Yvette Tache

Description : The expression of c-Fos defines brain regions activated by the stressors hypotension and glucoprivation however, whether this identifies all brain sites involved is unknown. Furthermore, the neurochemicals that delineate these regions, or are utilized in them when responding to these stressors remain undefined. Conscious rats were subjected to hypotension, glucoprivation or vehicle for 30, 60 or 120 min and changes in the phosphorylation of serine residues ...

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