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Plos One : Induced Tauopathy in a Novel 3D-culture Model Mediates ...

By: Akio Suzumura

Description : Tauopathies including Alzheimer’s disease represent one of the major health problems of aging population worldwide. Therefore, a better understanding of tau-dependent pathologies and consequently, tau-related intervention strategies is highly demanded. In recent years, several tau-focused therapies have been proposed with the aim to stop disease progression. However, to develop efficient active pharmaceutical ingredients for the broad treatment of Alzheimer...

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Plos One : the Neuronal Responses to Repetitive Acoustic Pulses in...

By: Bernd Sokolowski

Description : Cortical representation of time-varying features of acoustic signals is a fundamental issue of acoustic processing remaining unresolved. The rat is a widely used animal model for auditory cortical processing. Though some electrophysiological studies have investigated the neural responses to temporal repetitive sounds in the auditory cortex (AC) of rats, most of them were conducted under anesthetized condition. Recently, it has been shown that anesthesia cou...

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Plos One : Insights Into the N-sulfation Mechanism ; Molecular Dyn...

By: Emily Parker

Description : Sulfation patterns along glycosaminoglycan (GAG) chains dictate their functional role. The N-deacetylase N-sulfotransferase family (NDST) catalyzes the initial downstream modification of heparan sulfate and heparin chains by removing acetyl groups from subsets of N-acetylglucosamine units and, subsequently, sulfating the residual free amino groups. These enzymes transfer the sulfuryl group from 39-phosphoadenosine-59-phosphosulfate (PAPS), yielding sulfated...

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Plos One : Impact of Latent Infection Treatment in Indigenous Popu...

By: Madhukar Pai

Description : The aims of the present study were to identify risk factors associated with latent tuberculosis (TB), examine the development of active disease among contacts, and assess the effectiveness of treating latent infection in indigenous Brazilians from January 2006 to December 2011. This was a retrospective study consisting of 1,371 tuberculosis contacts, 392 of whom underwent treatment for latent infection. Morbidity-from-TB data were obtained from the Informat...

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Plos One : the Role of Ring Box Protein 1 in Mouse Oocyte Meiotic ...

By: Hongmei Wang

Description : RING box protein-1 (RBX1) is an essential component of Skp1-cullin-F-box protein (SCF) E3 ubiquitin ligase and participates in diverse cellular processes by targeting various substrates for degradation. However, the physiological function of RBX1 in mouse oocyte maturation remains unknown. Here, we examined the expression, localization and function of RBX1 during mouse oocyte meiotic maturation. Immunofluorescence analysis showed that RBX1 displayed dynamic...

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Plos One : Mutations in Lmna Modulate the Lamin a - Nesprin-2 Inte...

By: Alfred Lewin

Description : Mutations in Nesprin-2 and lamin A are characterised by complex genotype phenotype relations. Our data show that each mutation in LMNAanalysed here has a distinct impact on the interaction among both proteins that substantially explains how distinct mutations in widely expressed genes lead to the formation of phenotypically different diseases.

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Plos One : Oself3-1, an Ortholog of Arabidopsis Early Flowering 3,...

By: David Edward Somers

Description : Arabidopsis thaliana EARLY FLOWERING 3 (ELF3) as a zeitnehmer (time taker) is responsible for generation of circadian rhythm and regulation of photoperiodic flowering. There are two orthologs (OsELF3-1 and OsELF3-2) of ELF3 in rice (Oryza sativa), but their roles have not yet been fully identified. Here, we performed a functional characterization of OsELF3-1 and revealed it plays a more predominant role than OsELF3-2 in rice heading. Our results suggest OsE...

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Plos One : Prognostic Significance of C-reactive Protein Polymorph...

By: Kjetil Tasken

Description : Both the CRP SNP rs7553007 and KRAS/BRAF mutations were independent prognostic factors for CRC patients with synchronous liver metastasis.

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Plos One : Intragenomic Profiling Using Multicopy Genes ; the Rdna...

By: Mary Bryk

Description : Multicopy genes, like ribosomal RNA genes (rDNA), are widely used to describe and distinguish individuals. Despite concerted evolution that homogenizes a large number of rDNA gene copies, the presence of different gene variants within a genome has been reported. Characterization of an organism by defining every single variant of tens to thousands of rDNA repeat units present in a eukaryotic genome would be quite unreasonable. Here we provide an alternative ...

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Plos One : Methylenetetrahydrofolate Reductase Gene Polymorphism a...

By: Stuart Raleigh

Description : There does not appear to be compelling evidence of an association between the genotype at the rs1801133 polymorphism of the MTHFR gene and risk of type 2 DM.

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Plos One : Describing the Relationship Between Cat Bites and Human...

By: Martine Hausberger

Description : Data mining approaches have been increasingly applied to the electronic health record and have led to the discovery of numerous clinical associations. Recent data mining studies have suggested a potential association between cat bites and human depression. To explore this possible association in more detail we first used administrative diagnosis codes to identify patients with either depression or bites, drawn from a population of 1.3 million patients. We t...

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Plos One : Traditional Nets Interfere with the Uptake of Long- Las...

By: Philip Bejon

Description : Net preference can interfere with optimal LLIN use. In order to improve the number of effective days of LLIN protection per dollar spent, appropriate quantitative and qualitative methods for collecting information on net preference should be developed before any LLIN procurement decision is made.

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Plos One : Water Ecosystem Services in Northern Australia—how Much...

By: Matteo Convertino

Description : There is ongoing pressure to develop the largely unaltered Daly River catchment in northern Australia for agriculture. However, a choice experiment among people in the region and in Australia’s largest city, Sydney, shows that people are prepared to pay substantial amounts to maintain the quality of its ecosystem services. The total stated willingness-to-pay (WTP) for a Daly River conservation programme was about $300, of which people would be willing to pa...

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Plos One : Nonlinearities Lead to Qualitative Differences in Popul...

By: Nicholas J. Mills

Description : Since typically there are many predators feeding on most herbivores in natural communities, understanding multiple predator effects is critical for both community and applied ecology. Experiments of multiple predator effects on prey populations are extremely demanding, as the number of treatments and the amount of labour associated with these experiments increases exponentially with the number of species in question. Therefore, researchers tend to vary only...

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Plos One : Targeting of Beta Adrenergic Receptors Results in Thera...

By: Devanand Sarkar

Description : Therapeutic targeting of the beta-adrenergic receptors has recently shown remarkable efficacy in the treatment of benign vascular tumors such as infantile hemangiomas. As infantile hemangiomas are reported to express high levels of beta adrenergic receptors, we examined the expression of these receptors on more aggressive vascular tumors such as hemangioendotheliomas and angiosarcomas, revealing beta 1, 2, and 3 receptors were indeed present and therefore a...

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Plos One : Sema6B, Sema6C, and Sema6D Expression and Function Duri...

By: Brian Key

Description : In the vertebrate retina, the formation of neural circuits within discrete laminae is critical for the establishment of retinal visual function. Precise formation of retinal circuits requires the coordinated actions of adhesive and repulsive molecules, including repulsive transmembrane semaphorins (Sema6A, Sema5A, and Sema5B). These semaphorins signal through different Plexin A (PlexA) receptors, thereby regulating distinct aspects of retinal circuit assemb...

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Plos One : Detection of Soluble St2 in Human Follicular Fluid and ...

By: Kjetil Tasken

Description : Follicular fluid (FF) contains various cytokines that are involved with folliculogenesis, some of which have been shown to be associated with oocyte quality and the implantation potential of a resulting embryo. Several IL-1 family members have previously been identified in FF. This study investigates a newly identified member of the family, IL-33, and its receptor ST2, comparing values to those of FF Granulocyte-Colony Stimulating Factor (G-CSF) – a known p...

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Plos One : Hit-to-lead Development of the Chamigrane Endoperoxide ...

By: Sylvie Bisser

Description : We report the semi-synthetic optimization of the merulin class of endoperoxide natural products as development candidates against T. brucei. We have identified compounds with low nM antiparasitic activities and high selectivity indices against HeLa cells. These compounds can be produced economically in large quantities via a one step derivatization from the microbial fermentation broth isolate, making them encouraging lead candidates for further development.

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Plos One : Self-glycolipids Modulate Dendritic Cells Changing the ...

By: Lucia Gabriele

Description : The impact of glycolipids of non-mammalian origin on autoimmune inflammation has become widely recognized. Here we report that the naturally occurring mammalian glycolipids, sulfatide and b-GalCer, affect the differentiation and the quality of antigen presentation by monocyte-derived dendritic cells (DCs). In response to sulfatide and b-GalCer, monocytes develop into immature DCs with higher expression of HLA-DR and CD86 but lower expression of CD80, CD40 a...

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Plos One : Nitric Oxide Participates in Cold-inhibited Camellia Si...

By: Keqiang Wu

Description : Nitric oxide (NO) plays essential roles in many biotic and abiotic stresses in plant development procedures, including pollen tube growth. Here, effects of NO on cold stress inhibited pollen germination and tube growth in Camellia sinensis were investigated in vitro. The NO production, NO synthase (NOS)-like activity, cGMP content and proline (Pro) accumulation upon treatment with NO scavenger cPTIO, NOS inhibitor L-NNA, NO donor DEA NONOate, guanylate cycl...

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