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Plos One : Pnpla3 Gg Genotype and Carotid Atherosclerosis in Patie...

By: Erica Villa

Description : PNPLA3 GG genotype is associated with higher severity of carotid atherosclerosis in younger patients with NAFLD. Mechanisms underlying this association, and its clinical relevance need further investigations.

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Plos One : Chinese Specific Characteristics of Sporadic Creutzfeld...

By: Wang Zhan

Description : This is the first study to indicate that Chinese sCJD patients have a much earlier onset age and a longer disease duration than other populations, which is most likely related to racial differences. The longer disease duration may also be a probable characteristic of Asian populations. PET had high sensitivity for the diagnosis of sCJD.

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Plos One : Lesion Length Impacts Long Term Outcomes of Drug- Eluti...

By: Giuseppe Biondi-zoccai

Description : In our single-center prospective registry, lesion length defined in tertiles has no impact on the short-term (ISR) or long-term (MACE) outcomes of patients implanted with DES. In contrast, longer lesion correlates with higher ISR and MACE rates in BMS group.

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Plos One : Immunologic Response to Tumor Ablation with Irreversibl...

By: David J. Klinke

Description : These findings indicated that IRE could not only locally destroy the tumor but also change the status of cellular immunity in osteosarcoma-bearing rats. This provides experimental evidence for the clinical application of IRE in osteosarcoma treatment.

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Plos One : Quantifying Spatial Variability of Selected Soil Trace ...

By: Helmut Ahammer

Description : Multifractal techniques were utilized to quantify the spatial variability of selected soil trace elements and their scaling relationships in a 10.24-ha agricultural field in northeast China. 1024 soil samples were collected from the field and available Fe, Mn, Cu and Zn were measured in each sample. Descriptive results showed that Mn deficiencies were widespread throughout the field while Fe and Zn deficiencies tended to occur in patches. By estimating sing...

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Plos One : Transcriptional Events During the Recovery from Mrsa Lu...

By: Paul J. Planet

Description : Community associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging threat to human health throughout the world. Rodent MRSA pneumonia models mainly focus on the early innate immune responses to MRSA lung infection. However, the molecular pattern and mechanisms of recovery from MRSA lung infection are largely unknown. In this study, a sublethal mouse MRSA pneumonia model was employed to investigate late events during the recovery from ...

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Plos One : Penetrating Cations Enhance Uncoupling Activity of Anio...

By: Hendrik W. Van Veen

Description : Protonophorous uncouplers causing a partial decrease in mitochondrial membrane potential are promising candidates for therapeutic applications. Here we showed that hydrophobic penetrating cations specifically targeted to mitochondria in a membrane potential-driven fashion increased proton-translocating activity of the anionic uncouplers 2,4-dinitrophenol (DNP) and carbonylcyanide-p-trifluorophenylhydrazone (FCCP). In planar bilayer lipid membranes (BLM) sep...

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Plos One : Paediatric Acute Kidney Injury in a Tertiary Hospital i...

By: Antonio Carlos Seguro

Description : Acute kidney injury is common in children admitted to hospitals. The common causes remain primary kidney diseases, sepsis and malaria but the contribution of sepsis is rising while malaria and gastroenteritis are declining. Acute kidney injury-related mortality remains high.

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Plos One : Cinper ; an Interactive Web System for Pathway Predicti...

By: Christos A. Ouzounis

Description : We present a web-based network-construction system, CINPER (CSBL INteractive Pathway BuildER), to assist a user to build a user-specified gene network for a prokaryotic organism in an intuitive manner. CINPER builds a network model based on different types of information provided by the user and stored in the system. CINPER’s prediction process has four steps : (i) collection of template networks based on (partially) known pathways of related organism(s) fr...

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Plos One : Characterization of Haemaphysalis Flava Acari ; Ixodida...

By: Gordon Langsley

Description : Tick is one of important ectoparasites capable of causing direct damage to their hosts and also acts as vectors of relevant infectious agents. In the present study, the taxa of 10 ticks, collected from Qinling giant pandas (Ailuropoda melanoleuca qinlingensis) in Qinling Mountains of China in April 2010, were determined using morphology and molecular markers (nucleotide ITS2 rDNA and mitochondrial 16S). Microscopic observation demonstrated that the morpholo...

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Plos One : Re-imagining the Future ; Repetition Decreases Hippocam...

By: Bart Rypma

Description : Imagining or simulating future events has been shown to activate the anterior right hippocampus (RHC) more than remembering past events does. One fundamental difference between simulation and memory is that imagining future scenarios requires a more extensive constructive process than remembering past experiences does. Indeed, studies in which this constructive element is reduced or eliminated by ‘‘pre-imagining’’ events in a prior session do not report dif...

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Plos One : Structural and Functional Analysis of the Deaf-1 and Bs...

By: Ramón Campos-olivas

Description : DEAF-1 is an important transcriptional regulator that is required for embryonic development and is linked to clinical depression and suicidal behavior in humans. It comprises various structural domains, including a SAND domain that mediates DNA binding and a MYND domain, a cysteine-rich module organized in a Cys4-Cys2-His-Cys (C4-C2HC) tandem zinc binding motif. DEAF-1 transcription regulation activity is mediated through interactions with cofactors such as...

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Plos One : Predicting Insect Migration Density and Speed in the Da...

By: Zoe G. Davies

Description : Insect migration needs to be quantified if spatial and temporal patterns in populations are to be resolved. Yet so little ecology is understood above the flight boundary layer (i.e. .10 m) where in north-west Europe an estimated 3 billion insects km21 month21 comprising pests, beneficial insects and other species that contribute to biodiversity use the atmosphere to migrate. Consequently, we elucidate meteorological mechanisms principally related to wind sp...

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Plos One : Camkkb is Involved in Amp-activated Protein Kinase Acti...

By: Mengwei Zang

Description : AMP-activated protein kinase (AMPK) plays an important role in mediating energy metabolism and is controlled mainly by two upstream kinases, LKB1 or Ca2+/calmodulin-dependent protein kinase kinase-b (CaMKKb). Previously, we found that baicalin, one of the major flavonoids in a traditional Chinese herb medicine, Scutellaria baicalensis, protects against the development of hepatic steatosis in rats feeding with a high-fat diet by the activation of AMPK, but, ...

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Plos One : Into the Square and Out of the Box ; the Effects of Qua...

By: Alessandro Antonietti

Description : The objective of the present study was to investigate the body-cognitive relationship through behavioral and electrophysiological measures in an attempt to uncover the underlying mediating neuronal mechanism for movementinduced cognitive change. To this end we examined the effects of Quadrato Motor Training (QMT), a new whole-body training paradigm on cognitive performance, including creativity and reaction time tasks, and electrophysiological change, using...

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Plos One : Microrna-155 Modulates Treg and Th17 Cells Differentiat...

By: Gobardhan Das

Description : MicroRNA (miR)-155 is a critical player in both innate and adaptive immune responses. It can influence CD4+ T cell lineage choice. To clarify the role of miR-155 in CD4+ CD25+ regulatory T (Treg)/T helper (Th)17 cell differentiation and function, as well as the mechanism involved, we performed gain-and loss-of-function analysis by transfection pre-miR-155 and anti-miR- 155 into purified CD4+ T cells. The results showed that miR-155 positively regulated both...

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Plos One : Fruit and Seed Anatomy of Chenopodium and Related Gener...

By: Dorian Q. Fuller

Description : A comparative carpological study of 96 species of all clades formerly considered as the tribe Chenopodieae has been conducted for the first time. The results show important differences in the anatomical structure of the pericarp and seed coat between representatives of terminal clades including Chenopodium s.str.+Chenopodiastrum and the recently recognized genera Blitum, Oxybasis and Dysphania. Within Chenopodium the most significant changes in fruit and se...

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Plos One : Neurotoxicity of Prion Peptides Mimicking the Central D...

By: Jiyan Ma

Description : The physiological functions of PrPC remain enigmatic, but the central domain, comprising highly conserved regions of the protein may play an important role. Indeed, a large number of studies indicate that synthetic peptides containing residues 106–126 (CR) located in the central domain (CD, 95–133) of PrPC are neurotoxic. The central domain comprises two chemically distinct subdomains, the charge cluster (CC, 95–110) and a hydrophobic region (HR, 112–133). ...

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Plos One : Effects of Posidonia Oceanica Beach-cast on Germination...

By: Francesco De Bello

Description : Seagrass meadows play an important role in marine ecosystems. A part of seagrass production is also exported to adjacent coastal terrestrial systems, possibly influencing their functioning. In this work we experimentally analyzed the effect of Posidonia oceanica beach-cast on plant germination, growth, and nutrient uptake of two plant species (Cakile maritima and Elymus farctus) that grow on upper beaches and fore dunes along the Mediterranean coasts. We co...

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Plos One : Coevolution of Quantum and Classical Strategies on Evol...

By: Alain Barrat

Description : We study the coevolution of quantum and classical strategies on weighted and directed random networks in the realm of the prisoner’s dilemma game. During the evolution, agents can break and rewire their links with the aim of maximizing payoffs, and they can also adjust the weights to indicate preferences, either positive or negative, towards their neighbors. The network structure itself is thus also subject to evolution. Importantly, the directionality of l...

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