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Plos One : Structural Insight Into Inhibitor of Apoptosis Proteins...

By: Srinivasa M. Srinivasula

Description : Genetic alterations enhancing cell survival and suppressing apoptosis are hallmarks of cancer that significantly reduce the efficacy of chemotherapy or radiotherapy. The Inhibitor of Apoptosis Protein (IAP) family hosts conserved proteins in the apoptotic pathway whose over-expression, frequently found in tumours, potentiates survival and resistance to anticancer agents. In humans, IAPs comprise eight members hosting one or more structural Baculoviral IAP R...

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Plos One : Preferential Duplication of Intermodular Hub Genes ; an...

By: Ying Xu

Description : Whole genome protein-protein association networks are not random and their topological properties stem from genome evolution mechanisms. In fact, more connected, but less clustered proteins are related to genes that, in general, present more paralogs as compared to other genes, indicating frequent previous gene duplication episodes. On the other hand, genes related to conserved biological functions present few or no paralogs and yield proteins that are high...

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Plos One : Human Ubc9 is Involved in Intracellular Hiv-1 Env Stabi...

By: Hong Wanjin

Description : The cellular E2 Sumo conjugase, Ubc9 interacts with HIV-1 Gag, and is important for the assembly of infectious HIV-1 virions. In the previous study we demonstrated that in the absence of Ubc9, a defect in virion assembly was associated with decreased levels of mature intracellular Envelope (Env) that affected Env incorporation into virions and virion infectivity. We have further characterized the effect of Ubc9 knockdown on HIV Env processing and assembly. ...

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Plos One : High and Low Protein ; Carbohydrate Dietary Ratios Duri...

By: Raul M. Luque

Description : Imbalanced maternal nutrition during gestation can cause alterations of the hypothalamic-pituitary-adrenal (HPA) system in offspring. The present study investigated the effects of maternal low- and high-protein diets during gestation in pigs on the maternal-fetal HPA regulation and expression of the glucocorticoid receptor (GR), mineralocorticoid receptor (MR), 11bhydroxysteroid dehydrogenase 1 and 2 (11b-HSD1 and 11b-HSD2) and c-fos mRNAs in the placenta a...

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Plos One : the Global Burden of Visual Difficulty in Low, Middle, ...

By: John G. Meara

Description : One out of five adults in the WHS reported some degree of far visual difficulty. Given the importance of vision to living an independent life, better access to quality eye care services and life course factors affecting vision health (e.g. repeated eye infections, diet lacking vitamin A) must receive adequate attention and resources, especially in low and middle income countries.

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Plos One : Promyelocytic Leukemia Pml Protein Plays Important Role...

By: A. Neil Hotchin

Description : PML protein plays important roles in regulating cellular homeostasis. It forms PML nuclear bodies (PML-NBs) that act like nuclear relay stations and participate in many cellular functions. In this study, we have examined the proteome of mouse embryonic fibroblasts (MEFs) derived from normal (PML+/+) and PML knockout (PML2/2) mice. The aim was to identify proteins that were differentially expressed when MEFs were incapable of producing PML. Using comparative...

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Plos One : Meta-analysis of Cytochrome P-450 2C9 Polymorphism and ...

By: Pal Bela Szecsi

Description : This meta-analysis suggests that the CYP2C9 may not be associated with colorectal cancer development

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Plos One : Dogs Canis Familiaris Evaluate Humans on the Basis of D...

By: Elsa Addessi

Description : Reputation formation is a key component in the social interactions of many animal species. An evaluation of reputation is drawn from two principal sources : direct experience of an individual and indirect experience from observing that individual interacting with a third party. In the current study we investigated whether dogs use direct and/or indirect experience to choose between two human interactants. In the first experiment, subjects had direct interac...

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Plos One : Evaluation of Genome Sequencing Quality in Selected Pla...

By: Matteo Pellegrini

Description : The quality of plant genome sequences was found to be lower than envisaged and thus the rapid development of genome sequencing projects as well as research on bioinformatics tools and the algorithms of genome sequence assembly should provide increased processing and correction of genome sequences that have already been published.

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Plos One : Mir-203 Inhibits Cell Proliferation and Migration of Lu...

By: Jun Li

Description : PKCα (protein kinase C alpha, PRKCA) is an important protein involved in several steps of signaling pathways in lung cancer, and microRNAs (miRNAs) have also been shown to participate in lung carcinogenesis. However, it is not clear how PKCα and miRNAs are correlated in the disease. In this report, we aimed to identify novel miRNAs that target PKCα and to study their biological function. Using bioinformatics analysis, we predicted one novel candidate, miR-2...

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Plos One : the Clinical Characteristics, Carbapenem Resistance, an...

By: Riccardo Manganelli

Description : A. baumannii genospecies was an independent risk factor for mortality in patients with Acinetobacter bacteremia. Our results emphasize the importance of correct species identification of Acinetobacter blood isolates.

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Plos One : a Flexible Alternative to the Cox Proportional Hazards ...

By: Raya Khanin

Description : Prognostic models are often used to estimate the length of patient survival. The Cox proportional hazards model has traditionally been applied to assess the accuracy of prognostic models. However, it may be suboptimal due to the inflexibility to model the baseline survival function and when the proportional hazards assumption is violated. The aim of this study was to use internal validation to compare the predictive power of a flexible Royston-Parmar family...

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Plos One : Uniparental Markers in Italy Reveal a Sex-biased Geneti...

By: David Caramelli

Description : Located in the center of the Mediterranean landscape and with an extensive coastal line, the territory of what is today Italy has played an important role in the history of human settlements and movements of Southern Europe and the Mediterranean Basin. Populated since Paleolithic times, the complexity of human movements during the Neolithic, the Metal Ages and the most recent history of the two last millennia (involving the overlapping of different cultural...

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Plos One : Comparative Assessment of Cytokines and Other Inflammat...

By: Christian Schulz

Description : The most powerful predictor to differentiate between the non-infected and infected neonates before antibiotics was sCD163. The most powerful indicator for evaluation of prognosis is IL-6. sCD163 can be used alone to screen for sepsis in neonates before the results of blood culture are received.

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Plos One : Müller Cell Reactivity in Response to Photoreceptor Deg...

By: Ram Nagaraj

Description : Background : Retinal degeneration in transgenic rats that express a mutant cilia gene polycystin-2 (CMV-PKD2(1/703)HA) is characterized by initial photoreceptor degeneration and glial activation, followed by vasoregression and neuronal degeneration (Feng et al., 2009, PLoS One 4 : e7328). It is unknown whether glial activation contributes to neurovascular degeneration after photoreceptor degeneration. We characterized the reactivity of Mu¨ ller glial cells ...

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Plos One : Noisy Galvanic Vestibular Stimulation Modulates the Amp...

By: Yu-feng Zang

Description : Noisy galvanic vestibular stimulation has been associated with numerous cognitive and behavioural effects, such as enhancement of visual memory in healthy individuals, improvement of visual deficits in stroke patients, as well as possibly improvement of motor function in Parkinson’s disease: yet, the mechanism of action is unclear. Since Parkinson’s and other neuropsychiatric diseases are characterized by maladaptive dynamics of brain rhythms, we investigat...

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Plos One : Fas, Volume 8

By: Valli De Re

Description : FAS/FASL altered expression may cause tumor protecting immunomodulation, with a direct impact on patient prognosis. FAS expression was studied in 60 squamous cell carcinomas of the oral cavity. FAS expression did not show a significant association with tumor histopathological characteristics, but was significantly associated with lymph node positivity. FAS expression was significantly associated with disease specific death and negative FAS expression was an...

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Plos One : Association Between Proton Magnetic Resonance Spectrosc...

By: Bart Dermaut

Description : The aim of this study was to correlate magnetic resonance spectroscopy (MRS) measurements, including that for the Nacetyl aspartate (NAA)/creatine (Cr) ratio in the vermis (denoted V-NAA), right cerebellar hemisphere (R-NAA), and left (LNAA) cerebellar hemisphere, with the clinical scale for the assessment and rating of ataxia (SARA) score for patients with spinocerebellar ataxia (SCA) types 2, 3, and 6. A total of 24 patients with SCA2, 48 with SCA3, and 1...

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Plos One : Atm Deficiency Results in Accumulation of Dnatopoisomer...

By: Michal Hetman

Description : Accumulation of peptide-linked DNA breaks contributes to neurodegeration in humans. This is typified by defects in tyrosyl DNA phosphodiesterase 1 (TDP1) and human hereditary ataxia. TDP1 primarily operates at single-strand breaks (SSBs) created by oxidative stress or by collision of transcription machinery with topoisomerase I intermediates (Top1-CCs). Cellular and cell-free studies have shown that Top1 at stalled Top1-CCs is first degraded to a small pept...

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Plos One : Extracellular Matrix Collagen Alters Cell Proliferation...

By: Nikos K Karamanos

Description : Uterine leiomyomas (ULs) are benign tumors occurring in the majority of reproductive aged women. Despite the high prevalence of these tumors, little is known about their etiology. A hallmark of ULs is the excessive deposition of extracellular matrix (ECM), primarily collagens. Collagens are known to modulate cell behavior and function singularly or through interactions with integrins and growth factor-mediated mitogenic pathways. To better understand the pa...

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