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World Health Organization Publication : Year 2006 ; Issue 92416605...

By: G. M. Williams

Medical Reference Publication

The Committee took note of the extensive evidence for the genotoxicity of several members of this group of flavouring agents related to furan, including the clastogenicity of 2-furyl methyl ketone (No. 1503) in mouse bone marrow

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Clinical Trials in Cancer Research

By: Edmund A. Gehan

Government Reference Publication

Introduction: The randomized clinical trial was first used for the evaluation of cancer treatments in the mid-1950s (I). Inonly two decades, it has proven to be a useful way oicvlutintgh e relative r.ifcctiveneuftrriitmcnt, and bodv ui knowled-re has hecn developed which provides objective data about cancer treatments. The organization of comparative clinical trials through the cooperative groups program sponsored by the National Cancer Institute in the U.S. and clinical...

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Crs Report for Congress Received through the Crs Web Federal Prote...

By: Erin D. Williams

Summary: The Common Rule (45 CFR 46, Subpart A) governs research that is conducted on human beings if it is funded by one of 18 federal agencies. It requires a review of proposed research by an Institutional Review Board (IRB), the informed consent of research subjects, and institutional assurances of compliance with the regulations. In 1974, 45 CFR 46 was published following some cases of harm to human subjects, such as those caused by thalidomide drug trials and the Un...

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Report of the 33Rd Session of the Codex Committee on Food Additive...

By: Food and Agriculture Organization of the United Nations

Nutrition Reference Publication

Excerpt: The thirty-third Session of the Codex Committee on Food Additives and Contaminants reached the following conclusions: MATTERS FOR ADOPTION BY THE 24TH SESSION OF THE CODEX ALIMENTARIUS COMMISSION ... Forward several amendments to Table 3 (Additives with an Acceptable Daily Intake of ?Not Specified?) of the Codex General Standard for Food Additives (GSFA) to the Commission for final adoption at Step 5 of the Accelerated Procedure (para. 48) ... Forwarded several ...

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An Experimental and Clinical Research into Certain Problems Relati...

By: George Washington Crile
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Clinical Researches on Disease in India

By: Morehead, Charles, 1807-1882
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World Health Organization : Technical Report Series, No. 782: Moni...

By: M. J. Behbehani

Medical Reference Publication

INTRODUCTION The WHO Expert Committee on Monitoring and Evaluation of Oral Health met at the Intercountry Centre for Oral Health (ICOH) in Chiang Mai, Thailand, from 8 to 14 December 1987. In reviewing the WHO Oral Health Programme, the Expert Committee noted its logic, breadth and innovatory approach, as well as its efforts to adapt to new situations and needs. The early emphasis of the Programme was on epidemiological methods and surveys, and on the development of the ...

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Clinical Investigations in Medical Research Guidance and Procedures

By: Department of Defense

Government Reference Publication

Excerpt: This instruction implements AFPD 40-4, Clinical Investigation and Human Use in Medical Research. It provides guidance and procedures for conducting clinical investigations at medical treatment facilities (MTF), clinical investigation facilities (CIF), and other medical support centers. It establishes procedures for using human subjects as volunteers in scientific studies in the Medical Service. If you will be using animals in clinical investigations, refer to AF...

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Occurrence and Methods of Control of Chemical Contaminants in Foods

By: C. F. Jelinek

Government Reference Publication

Introduction: Incidents that release chemicals into the environment often occur as a result of human activities. Such chemicals, which include pesticides, other industrial chemical contaminants, metals, and radionuclides, can also enter food by accident or misuse during food handling or processing. The Food and Drug Administration (FDA) programs for monitoring and controlling levels of contaminants in foods, the results the agency has obtained, and the steps being taken ...

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Clinical Research Nih Has Implemented Key Provisions of the Clinic...

By: General Accounting Office

Government Accountability Integrity Reliability Office Collection

Excerpt: Results in Brief 3 Background 5 Growth in NIH?s Spending on Clinical Research Has Kept Pace with Total Spending 8 NIH Has Taken Steps to Improve Its Peer Review of Clinical Research 12 NIH Has Increased Its Support and Scope of GCRCs 14 NIH Has Increased Its Support of Clinical Research Career Development and Training 16 NIH Has Established an Extramural Loan Repayment Program for Clinical Investigators 20 Conclusion 22 Recommendation for Executive Action 22 Age...

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Carcinogen Adducts as an Indicator for the Public Health Risks of ...

By: Bruce P. Dunn

Government Reference Publication

Introduction: The exposure of aquatic organisms to carcinogenic chemicals has long been recognized. Considerable attention has been paid to the possibility of cancer in aquatic species as a result of exposure to environmental contaminants (I). However, less attention has been paid to the direct public health consequences of eating carciwgen-wntaminated aquatic foodstuffs. Recently, the discovery of high tumor frequencies in certain wild fish populations has focused publi...

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World Health Organization : Year 2005 ; The Special Programme for ...

By: World Health Organization

Medical Reference Publication

1. | INTRODUCTION Herbal and other traditional pharmacologic therapies are in widespread use throughout the world. Such widespread use suggests, but does not assure, that traditional medicines have a favourable risk-benefit ratio. Rather, traditional medicines may be regarded as a rich source of potentially attractive therapies. The actual benefits and risks remain to be evaluated by clinical trials supported and conducted according to the principles of modern clinical science.

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World Health Organization Fact Sheet, Year 2006, Volume 298: World...

By: World Health Organization

Medical Reference Publication

Ehrlich put forward the idea that the objective of chemical ,attack upon noxious micro-organisms should be to interfere with the metabolic processes of the parasite in a specific manner, so that the host itself be uninjured. At the time Ehrlich proposed this, however, relatively little was known about those metabolic processes n-hich could be injured or about how they could be injured. The result v7as that, even with this guiding principle, there was little opportunity t...

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An Experimental and Clinical Research into Certain Problems Relati...

By: George Washington Crile
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Gastroenterology Case Studies : A Compilation of 55 Clinical Studies

By: Sodeman, William A. (William Anthony), 1936; Boyd, William P

Henry IV, King of England, 1367-1413

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Bulletin of the World Health Organization : 2005; Volume 83, Numbe...

By: Maria Andersson

Medical Reference Publication

The great public health and economic importance of schistosomiasis in many tropical areas has led to a great deal of research being devoted to experimental chemotherapy. Since the discovery of lucanthone by Kikuth & Gonnert (1948) and Mauss (1948), more than 250 000 chemical substances have been tested for schistosomicidal activity (Standen, 1967). Most of this experimental work in the laboratory has been carried out in mice infected with Schistosoma mansoni. In spite of...

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Pharmaceutical Industry Research Credit Audit Guidelines

By: Internal Revenue Service

Preface and Overview: 2. Summary of Recommended Audit Procedures; 3. Overview of IRC Sections 174 and 41; 4. Product Development Process; a. Stage One - Preclinical/Discovery Research; i. Introduction:; ii. Documentation; iii. Preclinical Departments; 1. Biology; 2. Chemistry; 3. Pharmacology and Toxicology; 4. Drug Metabolism; 5. Protein Discovery; b. Stage Two - Clinical Development; i. Introduction:; ii. Clinical Departments; 1. Pharmaceutical Development; 2. Analytic...

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The Principles of Inorganic Chemistry

By: Ostwald, Wilhelm, 1853-1932; Findlay, Alexander, 1874 Tr

Country life ; Hygiene

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Clinical Psychiatry : A Text-Book for Students and Physicians

By: Allen Ross Diefendorf, Emil Kraepelin
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Animal Chemistry with Reference to the Physiology and Pathology of...

By: Simon, Johann Franz, 1807-1843; Day, George Edward, 1815-1872
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