World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Competitive Repair by Naturally Dispersed Repetitive Dna During Non-allelic Homologous Recombination, Volume 6

By Copenhaver, Gregory P.

Click here to view

Book Id: WPLBN0003929585
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Competitive Repair by Naturally Dispersed Repetitive Dna During Non-allelic Homologous Recombination, Volume 6  
Author: Copenhaver, Gregory P.
Volume: Volume 6
Language: English
Subject: Journals, Science, Genetics
Collection: Periodicals: Journal and Magazine Collection (Contemporary)
Subcollection: PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Description
Description : Genome rearrangements often result from non-allelic homologous recombination (NAHR) between repetitive DNA elements dispersed throughout the genome. Here we systematically analyze NAHR between Ty retrotransposons using a genome-wide approach that exploits unique features of Saccharomyces cerevisiae purebred and Saccharomyces cerevisiae/ Saccharomyces bayanus hybrid diploids. We find that DNA double-strand breaks (DSBs) induce NAHR–dependent rearrangements using Ty elements located 12 to 48 kilobases distal to the break site. This break-distal recombination (BDR) occurs frequently, even when allelic recombination can repair the break using the homolog. Robust BDR–dependent NAHR demonstrates that sequences very distal to DSBs can effectively compete with proximal sequences for repair of the break. In addition, our analysis of NAHR partner choice between Ty repeats shows that intrachromosomal Ty partners are preferred despite the abundance of potential interchromosomal Ty partners that share higher sequence identity. This competitive advantage of intrachromosomal Tys results from the relative efficiencies of different NAHR repair pathways. Finally, NAHR generates deleterious rearrangements more frequently when DSBs occur outside rather than within a Ty repeat. These findings yield insights into mechanisms of repeat-mediated genome rearrangements associated with evolution and cancer.

 

Click To View

Additional Books


  • Plos Genetics : Positional Cloning of Zi... (by )
  • Plos Genetics : the Essential Function o... (by )
  • Plos Genetics : Celf Family Rna–binding ... (by )
  • Plos Genetics : Dynamic Large-scale Chro... (by )
  • Plos Genetics : Complete Genome Sequence... (by )
  • Plos Genetics : Gγγ1, a Downstream Targe... (by )
  • Plos Genetics : Endless Forms Most Viral... (by )
  • Plos Genetics : Human Disease-associated... (by )
  • Plos Genetics : Unexpected Role for Heli... (by )
  • Plos Genetics : Genetic and Pharmacologi... (by )
  • Plos Genetics : Argonaute2 is Essential ... (by )
  • Plos Genetics : from Classical Genetics ... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Fair are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.