World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : a Computational Model to Predict Rat Ovarian Steroid Secretion from in Vitro Experiments with Endocrine Disruptors, Volume 7

By Porollo, Aleksey

Click here to view

Book Id: WPLBN0003932715
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : a Computational Model to Predict Rat Ovarian Steroid Secretion from in Vitro Experiments with Endocrine Disruptors, Volume 7  
Author: Porollo, Aleksey
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Porollo, A. (n.d.). Plos One : a Computational Model to Predict Rat Ovarian Steroid Secretion from in Vitro Experiments with Endocrine Disruptors, Volume 7. Retrieved from http://worldebookfair.com/


Description
Description : A finely tuned balance between estrogens and androgens controls reproductive functions, and the last step of steroidogenesis plays a key role in maintaining that balance. Environmental toxicants are a serious health concern, and numerous studies have been devoted to studying the effects of endocrine disrupting chemicals (EDCs). The effects of EDCs on steroidogenic enzymes may influence steroid secretion and thus lead to reproductive toxicity. To predict hormonal balance disruption on the basis of data on aromatase activity and mRNA level modulation obtained in vitro on granulosa cells, we developed a mathematical model for the last gonadal steps of the sex steroid synthesis pathway. The model can simulate the ovarian synthesis and secretion of estrone, estradiol, androstenedione, and testosterone, and their response to endocrine disruption. The model is able to predict ovarian sex steroid concentrations under normal estrous cycle in female rat, and ovarian estradiol concentrations in adult female rats exposed to atrazine, bisphenol A, metabolites of methoxychlor or vinclozolin, and letrozole.

 

Click To View

Additional Books


  • Plos One : Mutation in E1, the Ubiquitin... (by )
  • Plos One : Programmatically Selected Mul... (by )
  • Plos One : Human Papillomavirus Type 6 a... (by )
  • Plos One : Origin and Diversification of... (by )
  • Plos One : the Ins and Outs of the Bccao... (by )
  • Plos One : West Africa - a Safe Haven fo... (by )
  • Plos One : a Trafficking-deficient Mutan... (by )
  • Plos One : Molecular Identification of C... (by )
  • Plos One : Risk Factors Associated with ... (by )
  • Plos One : Temporal Processing and Speec... (by )
  • Plos One : Local Adaptation to Altitude ... (by )
  • Plos One : Preference for Orientations C... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Fair are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.