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Plos One : Different Patterns of Cytokines and Chemokines Combined with Ifn-c Production Reflect Mycobacterium Tuberculosis Infection and Disease, Volume 7

By Ahuja, Sunil K.

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Book Id: WPLBN0003936185
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Different Patterns of Cytokines and Chemokines Combined with Ifn-c Production Reflect Mycobacterium Tuberculosis Infection and Disease, Volume 7  
Author: Ahuja, Sunil K.
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

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Ahuja, S. K. (n.d.). Plos One : Different Patterns of Cytokines and Chemokines Combined with Ifn-c Production Reflect Mycobacterium Tuberculosis Infection and Disease, Volume 7. Retrieved from http://worldebookfair.com/


Description
Description : For the 41 examined factors, our results indicated that three patterns were closely associated with infection and disease. (1) Significantly elevated plasma levels of IL-2, IP-10, CXCL11 and CXCL12 were present in both patients with tuberculosis and in a sub-group participant with latent tuberculosis infection who showed a higher level of IFN-c producing cells by ELISPOT assay compared with other latently infected individuals. (2) IL-6 and IL-9 were only significantly increased in plasma from active TB patients, and the two factors were consistently highly secreted after M.tb antigen stimulation. (3) When patients developed tuberculous pleurisy, CCL1, CCL21 and IL-6 were specifically increased in the pleural effusions. In particular, these three factors were consistently highly secreted by pleural fluid mononuclear cells following M.tb-specific antigen stimulation. In conclusion, our data imply that the specific secretion of soluble immunological factors, in addition to IFN-c, may be used to evaluate M.tb infection and tuberculosis disease.

 

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