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Plos One : Identification of a Drosophila Glucose Receptor Using CA2+ Imaging of Single Chemosensory Neurons, Volume 7

By Meyerhof, Wolfgang

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Book Id: WPLBN0003938904
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Identification of a Drosophila Glucose Receptor Using CA2+ Imaging of Single Chemosensory Neurons, Volume 7  
Author: Meyerhof, Wolfgang
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

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Meyerhof, W. (n.d.). Plos One : Identification of a Drosophila Glucose Receptor Using CA2+ Imaging of Single Chemosensory Neurons, Volume 7. Retrieved from http://worldebookfair.com/


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Description : Evaluation of food compounds by chemosensory cells is essential for animals to make appropriate feeding decisions. In the fruit fly Drosophila melanogaster, structurally diverse chemicals are detected by multimeric receptors composed of members of a large family of Gustatory receptor (Gr) proteins. Putative sugar and bitter receptors are expressed in distinct subsets of Gustatory Receptor Neurons (GRN) of taste sensilla, thereby assigning distinct taste qualities to sugars and bitter tasting compounds, respectively. Here we report a Ca2+ imaging method that allows association of ligand-mediated responses to a single GRN. We find that different sweet neurons exhibit distinct response profiles when stimulated with various sugars, and likewise, different bitter neurons exhibit distinct response profiles when stimulated with a set of bitter chemicals. These observations suggest that individual neurons within a taste modality are represented by distinct repertoires of sweet and bitter taste receptors, respectively. Furthermore, we employed this novel method to identify glucose as the primary ligand for the sugar receptor Gr61a, which is not only expressed in sweet sensing neurons of classical chemosensory sensilla, but also in two supersensitive neurons of atypical taste sensilla. Thus, single cell Ca2+ imaging can be employed as a powerful tool to identify ligands for orphan Gr proteins.

 

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