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Plos One : MacRophages, Nitric Oxide and Micrornas Are Associated with Dna Damage Response Pathway and Senescence in Inflammatory Bowel Disease, Volume 7

By Foligne, Benoit

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Book Id: WPLBN0003940351
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : MacRophages, Nitric Oxide and Micrornas Are Associated with Dna Damage Response Pathway and Senescence in Inflammatory Bowel Disease, Volume 7  
Author: Foligne, Benoit
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
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Publisher: Plos

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Foligne, B. (n.d.). Plos One : MacRophages, Nitric Oxide and Micrornas Are Associated with Dna Damage Response Pathway and Senescence in Inflammatory Bowel Disease, Volume 7. Retrieved from http://worldebookfair.com/


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Description : Senescence was observed in IBD with senescence-associated b-galactosidase and HP1c. Macrophages were associated with senescence and DDR in UC, and in vitro experiments with primary human cells showed that macrophages induce senescence, partly through NON, and that NON can induce DDR associated with senescence. Future experiments will investigate the role of NON and miR-21 in senescence. This is the first study to implicate macrophages and nitrosative stress in a direct effect on senescence and DDR, which is relevant to many diseases of inflammation, cancer, and aging.

 

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