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Plos Genetics : Grhl3, Volume 8

By Bickmore, Wendy A.

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Book Id: WPLBN0003941813
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : Grhl3, Volume 8  
Author: Bickmore, Wendy A.
Volume: Volume 8
Language: English
Subject: Journals, Science, Genetics
Collection: Periodicals: Journal and Magazine Collection
Subcollection: PLoS Genetics
Publication Date:
Publisher: Plos

Description : The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous work has shown that release from Polycomb repression only partially explains differentiation gene activation. We now show that Trithorax is also a key regulator of epidermal differentiation, not only through activation of genes repressed by Polycomb in progenitor cells, but also through activation of genes independent of regulation by Polycomb. The differentiation associated transcription factor GRHL3/GET1 recruits the ubiquitously expressed Trithorax complex to a subset of differentiation genes.


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