World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Cooperative Rna Polymerase Molecules Behavior on a Stochastic Sequence-dependent Model for Transcription Elongation, Volume 8

By Levy,yaakov Koby

Click here to view

Book Id: WPLBN0003945987
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Cooperative Rna Polymerase Molecules Behavior on a Stochastic Sequence-dependent Model for Transcription Elongation, Volume 8  
Author: Levy,yaakov Koby
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Levy, Y. K. (n.d.). Plos One : Cooperative Rna Polymerase Molecules Behavior on a Stochastic Sequence-dependent Model for Transcription Elongation, Volume 8. Retrieved from http://worldebookfair.com/


Description
Description : The transcription process is crucial to life and the enzyme RNA polymerase (RNAP) is the major component of the transcription machinery. The development of single-molecule techniques, such as magnetic and optical tweezers, atomicforce microscopy and single-molecule fluorescence, increased our understanding of the transcription process and complements traditional biochemical studies. Based on these studies, theoretical models have been proposed to explain and predict the kinetics of the RNAP during the polymerization, highlighting the results achieved by models based on the thermodynamic stability of the transcription elongation complex. However, experiments showed that if more than one RNAP initiates from the same promoter, the transcription behavior slightly changes and new phenomenona are observed. We proposed and implemented a theoretical model that considers collisions between RNAPs and predicts their cooperative behavior during multi-round transcription generalizing the Bai et al. stochastic sequence-dependent model. In our approach, collisions between elongating enzymes modify their transcription rate values. We performed the simulations in MathematicaH and compared the results of the single and the multiple-molecule transcription with experimental results and other theoretical models. Our multi-round approach can recover several expected behaviors, showing that the transcription process for the studied sequences can be accelerated up to 48% when collisions are allowed : the dwell times on pause sites are reduced as well as the distance that the RNAPs backtracked from backtracking sites.

 

Click To View

Additional Books


  • Plos One : Majority Rules with Random Ti... (by )
  • Plos One : Neonatal Thyroid-stimulating ... (by )
  • Plos One : Risk Factors for Late-life Co... (by )
  • Plos One : Khz Fusion of Ganoderma Lucid... (by )
  • Plos One : Single Amino Acid Substitutio... (by )
  • Plos One : Norcantharidin Inhibits Renal... (by )
  • Plos One : Clmp is Essential for Intesti... (by )
  • Plos One : Genetic Associations with Dia... (by )
  • Plos One : Correlation Between Human Leu... (by )
  • Plos One : Systemic Delivery of Recombin... (by )
  • Plos One : Identification of Novel Adhes... (by )
  • Plos One : Positive Outcomes Influence t... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Fair are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.