World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Intra- and Inter-frequency Brain Network Structure in Health and Schizophrenia, Volume 8

By Hayasaka, Satoru

Click here to view

Book Id: WPLBN0003950929
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Intra- and Inter-frequency Brain Network Structure in Health and Schizophrenia, Volume 8  
Author: Hayasaka, Satoru
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Publication Date:
Publisher: Plos


APA MLA Chicago

Hayasaka, S. (n.d.). Plos One : Intra- and Inter-frequency Brain Network Structure in Health and Schizophrenia, Volume 8. Retrieved from

Description : Empirical studies over the past two decades have provided support for the hypothesis that schizophrenia is characterized by altered connectivity patterns in functional brain networks. These alterations have been proposed as genetically mediated diagnostic biomarkers and are thought to underlie altered cognitive functions such as working memory. However, the nature of this dysconnectivity remains far from understood. In this study, we perform an extensive analysis of functional connectivity patterns extracted from MEG data in 14 subjects with schizophrenia and 14 healthy controls during a 2-back working memory task. We investigate uni-, bi- and multivariate properties of sensor time series by computing wavelet entropy of and correlation between time series, and by constructing binary networks of functional connectivity both within and between classical frequency bands (c, b, a, and h). Networks are based on the mutual information between wavelet time series, and estimated for each trial window separately, enabling us to consider both network topology and network dynamics. We observed significant decreases in time series entropy and significant increases in functional connectivity in the schizophrenia group in comparison to the healthy controls and identified an inverse relationship between these measures across both subjects and sensors that varied over frequency bands and was more pronounced in controls than in patients. The topological organization of connectivity was altered in schizophrenia specifically in high frequency c and b band networks as well as in the c-b cross-frequency networks. Network topology varied over trials to a greater extent in patients than in controls, suggesting disease-associated alterations in dynamic network properties of brain function. Our results identify signatures of aberrant neurophysiological behavior in schizophrenia across uni-, bi- and multivariate scales and lay the groundwork for further clinical studies that might lead to the discovery of new intermediate phenotypes


Click To View

Additional Books

  • Plos One : Transcription Factors That Co... (by )
  • Plos One : Generation and Characterisati... (by )
  • Plos One : Pparc Agonists Promote Oligod... (by )
  • Plos One : Job Preferences of Nurses and... (by )
  • Plos One : Whole Genome Gene Expression ... (by )
  • Plos One : Two Functional Motifs Define ... (by )
  • Plos One : Genomic Copy Number Variants ... (by )
  • Plos One : N300 and Social Affordances ;... (by )
  • Plos One : Structural Basis of the Induc... (by )
  • Plos One : Pharmacokinetics Study of Rec... (by )
  • Plos One : Effect of Ambient Temperature... (by )
  • Plos One : Characterization of the Molec... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Fair are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.