World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Mir-22 Controls Irf8 Mrna Abundance and Murine Dendritic Cell Development, Volume 7

By Kovats, Susan

Click here to view

Book Id: WPLBN0003956895
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Mir-22 Controls Irf8 Mrna Abundance and Murine Dendritic Cell Development, Volume 7  
Author: Kovats, Susan
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Kovats, S. (n.d.). Plos One : Mir-22 Controls Irf8 Mrna Abundance and Murine Dendritic Cell Development, Volume 7. Retrieved from http://worldebookfair.com/


Description
Description : MicroRNAs (miRNAs) have emerged as critical regulators of many cellular responses, through the action of miRNA-induced silencing complex (miRISC)- or miRNA ribonucleoprotein complex (miRNP)-mediated gene repression. Here we studied the role of miRNAs in the development of dendritic cells (DCs), an important immune cell type that is divided into conventional DC (cDC) and plasmacytoid DC (pDC) subsets. We found that miR-22 was highly expressed in mouse CD11c+ CD11b+ B2202 cDCs compared to pDCs, and was induced in DC progenitor cell cultures with GM-CSF, which stimulate CD11c+ CD11b+ B2202 cDC differentiation. Enforced overexpression of miR-22 during DC development enhanced CD11c+ CD11b+ B2202 cDC generation at the expense of pDCs, while miR-22 knockdown demonstrated opposite effects. Moreover, overexpression and knockdown of miR-22 showed significant effects on the mRNA abundance of Irf8, which encodes the transcription factor IRF8 that plays essential roles in DC development. Luciferase reporter assays confirmed that miR-22 binds directly to the 39UTR of the mouse Irf8 mRNA. Collectively, these results suggest that miR-22 targets Irf8 mRNA for posttranscriptional repression and controls DC subset differentiation.

 

Click To View

Additional Books


  • Plos One : Population Expanding with the... (by )
  • Plos One : the Secretome of Alginate-enc... (by )
  • Plos One : Paranode Abnormalities and Ox... (by )
  • Plos One : Internet-based Screening for ... (by )
  • Plos One : Multi-platform Analysis of Mi... (by )
  • Plos One : Blunted Sodium Excretion in R... (by )
  • Plos One : Hard and Transparent Films Fo... (by )
  • Plos One : Why the Long Face the Mechani... (by )
  • Plos One : Analysis and Optimization of ... (by )
  • Plos One : Proton Nmr-based Metabolite A... (by )
  • Plos One : Abnormal Expression of the Pr... (by )
  • Plos One : the Dental Plaque Microbiome ... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Fair are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.