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Plos One : Mir-22 Controls Irf8 Mrna Abundance and Murine Dendritic Cell Development, Volume 7

By Kovats, Susan

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Book Id: WPLBN0003956895
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Mir-22 Controls Irf8 Mrna Abundance and Murine Dendritic Cell Development, Volume 7  
Author: Kovats, Susan
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Publication Date:
Publisher: Plos


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Kovats, S. (n.d.). Plos One : Mir-22 Controls Irf8 Mrna Abundance and Murine Dendritic Cell Development, Volume 7. Retrieved from

Description : MicroRNAs (miRNAs) have emerged as critical regulators of many cellular responses, through the action of miRNA-induced silencing complex (miRISC)- or miRNA ribonucleoprotein complex (miRNP)-mediated gene repression. Here we studied the role of miRNAs in the development of dendritic cells (DCs), an important immune cell type that is divided into conventional DC (cDC) and plasmacytoid DC (pDC) subsets. We found that miR-22 was highly expressed in mouse CD11c+ CD11b+ B2202 cDCs compared to pDCs, and was induced in DC progenitor cell cultures with GM-CSF, which stimulate CD11c+ CD11b+ B2202 cDC differentiation. Enforced overexpression of miR-22 during DC development enhanced CD11c+ CD11b+ B2202 cDC generation at the expense of pDCs, while miR-22 knockdown demonstrated opposite effects. Moreover, overexpression and knockdown of miR-22 showed significant effects on the mRNA abundance of Irf8, which encodes the transcription factor IRF8 that plays essential roles in DC development. Luciferase reporter assays confirmed that miR-22 binds directly to the 39UTR of the mouse Irf8 mRNA. Collectively, these results suggest that miR-22 targets Irf8 mRNA for posttranscriptional repression and controls DC subset differentiation.


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