World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : the Prognosis of Allocentric and Egocentric Neglect ; Evidence from Clinical Scans, Volume 7

By Baron, Jean-claude

Click here to view

Book Id: WPLBN0003961375
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : the Prognosis of Allocentric and Egocentric Neglect ; Evidence from Clinical Scans, Volume 7  
Author: Baron, Jean-claude
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Publication Date:
Publisher: Plos


APA MLA Chicago

Baron, J. (n.d.). Plos One : the Prognosis of Allocentric and Egocentric Neglect ; Evidence from Clinical Scans, Volume 7. Retrieved from

Description : We contrasted the neuroanatomical substrates of sub-acute and chronic visuospatial deficits associated with different aspects of unilateral neglect using computed tomography scans acquired as part of routine clinical diagnosis. Voxel-wise statistical analyses were conducted on a group of 160 stroke patients scanned at a sub-acute stage. Lesion-deficit relationships were assessed across the whole brain, separately for grey and white matter. We assessed lesions that were associated with behavioural performance (i) at a sub-acute stage (within 3 months of the stroke) and (ii) at a chronic stage (after 9 months post stroke). Allocentric and egocentric neglect symptoms at the sub-acute stage were associated with lesions to dissociated regions within the frontal lobe, amongst other regions. However the frontal lesions were not associated with neglect at the chronic stage. On the other hand, lesions in the angular gyrus were associated with persistent allocentric neglect. In contrast, lesions within the superior temporal gyrus extending into the supramarginal gyrus, as well as lesions within the basal ganglia and insula, were associated with persistent egocentric neglect. Damage within the temporoparietal junction was associated with both types of neglect at the sub-acute stage and 9 months later. Furthermore, white matter disconnections resulting from damage along the superior longitudinal fasciculus were associated with both types of neglect and critically related to both sub-acute and chronic deficits. Finally, there was a significant difference in the lesion volume between patients who recovered from neglect and patients with chronic deficits. The findings presented provide evidence that (i) the lesion location and lesion size can be used to successfully predict the outcome of neglect based on clinical CT scans, (ii) lesion location alone can serve as a critical predictor for persistent neglect symptoms, (iii) wide spread lesions are associated with neglect symptoms at the sub-acute stage but only some of these are critical for predicting whether neglect will become a chronic disorder and (iv) the severity of behavioural symptoms can be a useful predictor of recovery in the absence of neuroimaging findings on clinical scans. We discuss the implications for understanding the symptoms of the neglect syndrome, the recovery of function and the use of clinical scans to predict outcome.


Click To View

Additional Books

  • Plos One : Development of Transgenic Mic... (by )
  • Plos One : Imaging Beads-retained Prey A... (by )
  • Plos One : Distinctive Genes Determine D... (by )
  • Plos One : Nicotinamide Mononucleotide A... (by )
  • Plos One : Gtp Cyclohydrolase I and Tyro... (by )
  • Plos One : an Integrated Proteomic and M... (by )
  • Plos One : Myosin7A Deficiency Results i... (by )
  • Plos One : Xanthurenic Acid Binds to Neu... (by )
  • Plos One : is the Oxidant, Volume 8 (by )
  • Plos One : a Computational Model of Lipo... (by )
  • Plos One : a Fast Universal Immobilizati... (by )
  • Plos One : Molecular Modeling Studies of... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Fair are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.