World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Mir-203 Inhibits Cell Proliferation and Migration of Lung Cancer Cells by Targeting Pkcα, Volume 8

By Li, Jun

Click here to view

Book Id: WPLBN0003963176
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Mir-203 Inhibits Cell Proliferation and Migration of Lung Cancer Cells by Targeting Pkcα, Volume 8  
Author: Li, Jun
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Li, J. (n.d.). Plos One : Mir-203 Inhibits Cell Proliferation and Migration of Lung Cancer Cells by Targeting Pkcα, Volume 8. Retrieved from http://worldebookfair.com/


Description
Description : PKCα (protein kinase C alpha, PRKCA) is an important protein involved in several steps of signaling pathways in lung cancer, and microRNAs (miRNAs) have also been shown to participate in lung carcinogenesis. However, it is not clear how PKCα and miRNAs are correlated in the disease. In this report, we aimed to identify novel miRNAs that target PKCα and to study their biological function. Using bioinformatics analysis, we predicted one novel candidate, miR-203, and found differential expression patterns of miR-203 and PKCα in human lung cancer tissues. Moreover, we experimentally validated miR-203 as a direct regulator of PKCα. Finally, we demonstrated that the targeting of PKCα by miR-203 played a critical role in regulating cell proliferation, apoptosis and migration in lung cancer cells. In summary, this study identifies a novel miRNA that targets PKCα and illustrates that the downregulation of PKCα by miR-203 modulates biological processes in lung cancer cells.

 

Click To View

Additional Books


  • Plos One : Binding of Tcr Multimers and ... (by )
  • Plos One : Purification and Characteriza... (by )
  • Plos One : Molecular Species Delimitatio... (by )
  • Plos One : Black Tea High-molecular-weig... (by )
  • Plos One : Formal Comparison of Dual-par... (by )
  • Plos One : Ros-dependent Mitochondria Mo... (by )
  • Plos One : Prognostic Value of Hpv E6, V... (by )
  • Plos One : a Simple 2D Non-parametric Re... (by )
  • Plos One : the Human Urine Metabolome, V... (by )
  • Plos One : Bone Plasticity in Response t... (by )
  • Plos One : Rapid Diagnosis of Bloodstrea... (by )
  • Plos One : a Kinetic-based Model of Radi... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Fair are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.