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Plos One : Population Genomics of Cardiometabolic Traits ; Design of the University College London-london School of Hygiene and Tropical Medicine-edinburgh-bristol Ucleb Consortium, Volume 8

By Zeller, Tanja

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Book Id: WPLBN0003964889
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Population Genomics of Cardiometabolic Traits ; Design of the University College London-london School of Hygiene and Tropical Medicine-edinburgh-bristol Ucleb Consortium, Volume 8  
Author: Zeller, Tanja
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

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Zeller, T. (n.d.). Plos One : Population Genomics of Cardiometabolic Traits ; Design of the University College London-london School of Hygiene and Tropical Medicine-edinburgh-bristol Ucleb Consortium, Volume 8. Retrieved from http://worldebookfair.com/


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Description : Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highlyphenotyped population-based prospective studies, aims to : (1) fine map functionally relevant SNPs: (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination: (3) investigate mechanisms leading to altered risk factor profiles and CVD events: and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.

 

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