World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Potentiation of Scutellarinon Human Tongue Carcinoma Xenograftby Low-intensity Ultrasound, Volume 8

By Miller, W. Todd

Click here to view

Book Id: WPLBN0003964971
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Potentiation of Scutellarinon Human Tongue Carcinoma Xenograftby Low-intensity Ultrasound, Volume 8  
Author: Miller, W. Todd
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Publication Date:
Publisher: Plos


APA MLA Chicago

Miller, W. T. (n.d.). Plos One : Potentiation of Scutellarinon Human Tongue Carcinoma Xenograftby Low-intensity Ultrasound, Volume 8. Retrieved from

Description : Scutellarin 7-O-β-D-glucuronide (scutellarin) has shown great potential as a chemotherapeutic agent for cancer treatment, but only at high dosage. Here we investigate the possibility of using low intensity ultrasound to reduce the scutellarin dosage. Ultrasound intensities of 1.0 W/cm2 and 0.05 W/cm2 were used for in vivo and in vitro experiments, respectively, and a very low dosage of scutellarin (15 nM) was used. Tumor-bearing Balb/c mice and SAS human-tongue squamous carcinoma cell suspensions were used for the in vivo and in vitro experiments, respectively. Each kind of subjects was divided into control, ultrasound-alone, scutellarin-alone, and combined ultrasound-scutellarin treatment groups. Only the combined treatment showed strong anticancer effects. In the in vivo case, the combined treatment significantly delayed tumor growth, initiated cellular chromatin changes (including a decrease in the number of cytoplasmic organelles and fragmentation of condensed nuclear chromatin), inhibited tumor angiogenesis and lymphangiogenesis, stopped cancer-cell proliferation, decreased MMP-2 and MMP-9 expression levels and caused cancer-cell apoptosis. In the in vitro case, the combined treatment produced cancer cell-shape irregularity in a manner seriously fractured microvilli, inhibited cancer-cell migratory and invasion activities, and induced cancer-cell apoptosis. Because the combined treatment did not increase intracellular ROS production, scutellarin is not a sonosensitizer so that the anticancer effect is not through sonodynamic therapy. Low-intensity ultrasound is merely increasing the permeability of scutellarin into cancer cells. Based on our results, one may perform localized chemotherapy using much reduced dosage of the drug with the help of low intensity ultrasound, which will greatly minimize side effects.


Click To View

Additional Books

  • Plos One : Contrast-enhanced Ultrasound ... (by )
  • Plos One : Discovery of a Novel Dual Fun... (by )
  • Plos One : Enhanced Ab1–40 Production in... (by )
  • Plos One : Ethnic Differences in Disabil... (by )
  • Plos One : Modelling Temporal Stability ... (by )
  • Plos One : Dynamic Regulation of Phenyla... (by )
  • Plos One : Identification and Characteri... (by )
  • Plos One : Individual Differences in Det... (by )
  • Plos One : Patterns of Distribution of t... (by )
  • Plos One : Hypothermia Activates Adipose... (by )
  • Plos One : Mutation in Phex Gene Predisp... (by )
  • Plos One : Central Auditory Masking by a... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Fair are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.