World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Rectal Transmission of Transmitted, Volume 8

By Tachedjian, Gilda

Click here to view

Book Id: WPLBN0003965778
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Rectal Transmission of Transmitted, Volume 8  
Author: Tachedjian, Gilda
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Tachedjian, G. (n.d.). Plos One : Rectal Transmission of Transmitted, Volume 8. Retrieved from http://worldebookfair.com/


Description
Description : Rectal microbicides are being developed to prevent new HIV infections in both men and women. We focused our in vivo preclinical efficacy study on rectally-applied tenofovir. BLT humanized mice (n = 43) were rectally inoculated with either the primary isolate HIV-1JRCSF or the MSM-derived transmitted/founder (T/F) virus HIV-1THRO within 30 minutes following treatment with topical 1% tenofovir or vehicle. Under our experimental conditions, in the absence of drug treatment we observed 50% and 60% rectal transmission by HIV-1JRCSF and HIV-1THRO, respectively. Topical tenofovir reduced rectal transmission to 8% (1/12: log rank p = 0.03) for HIV-1JRCSF and 0% (0/6: log rank p = 0.02) for HIV-1THRO. This is the first demonstration that any human T/F HIV-1 rectally infects humanized mice and that transmission of the T/F virus can be efficiently blocked by rectally applied 1% tenofovir. These results obtained in BLT mice, along with recent ex vivo, Phase 1 trial and non-human primate reports, provide a critically important step forward in the development of tenofovir-based rectal microbicides.

 

Click To View

Additional Books


  • Plos One : Dna Fingerprinting of Chinese... (by )
  • Plos One : Correlative in Vivo 2 Photon ... (by )
  • Plos One : Examination of Artificial Mir... (by )
  • Plos One : Rnai Screening in Primary Hum... (by )
  • Plos One : Genetic Variability in L1 and... (by )
  • Plos One : Monitoring of Single-cell Res... (by )
  • Plos One : Effects of Two Commonly Found... (by )
  • Plos One : S100P Expression is a Novel P... (by )
  • Plos One : Implication of Progranulin an... (by )
  • Plos One : Differences Between Adiposity... (by )
  • Plos One : High and Distinct Range-edge ... (by )
  • Plos One : Fop is a Centriolar Satellite... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Fair are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.