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Plos One : Rectal Transmission of Transmitted, Volume 8

By Tachedjian, Gilda

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Book Id: WPLBN0003965778
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Rectal Transmission of Transmitted, Volume 8  
Author: Tachedjian, Gilda
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Publication Date:
Publisher: Plos


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Tachedjian, G. (n.d.). Plos One : Rectal Transmission of Transmitted, Volume 8. Retrieved from

Description : Rectal microbicides are being developed to prevent new HIV infections in both men and women. We focused our in vivo preclinical efficacy study on rectally-applied tenofovir. BLT humanized mice (n = 43) were rectally inoculated with either the primary isolate HIV-1JRCSF or the MSM-derived transmitted/founder (T/F) virus HIV-1THRO within 30 minutes following treatment with topical 1% tenofovir or vehicle. Under our experimental conditions, in the absence of drug treatment we observed 50% and 60% rectal transmission by HIV-1JRCSF and HIV-1THRO, respectively. Topical tenofovir reduced rectal transmission to 8% (1/12: log rank p = 0.03) for HIV-1JRCSF and 0% (0/6: log rank p = 0.02) for HIV-1THRO. This is the first demonstration that any human T/F HIV-1 rectally infects humanized mice and that transmission of the T/F virus can be efficiently blocked by rectally applied 1% tenofovir. These results obtained in BLT mice, along with recent ex vivo, Phase 1 trial and non-human primate reports, provide a critically important step forward in the development of tenofovir-based rectal microbicides.


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