World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Var2Csa Signatures of High Plasmodium Falciparum Parasitemia in the Placenta, Volume 8

By Carvalho, Luzia Helena

Click here to view

Book Id: WPLBN0003969324
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Var2Csa Signatures of High Plasmodium Falciparum Parasitemia in the Placenta, Volume 8  
Author: Carvalho, Luzia Helena
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Publication Date:
Publisher: Plos


APA MLA Chicago

Carvalho, L. H. (n.d.). Plos One : Var2Csa Signatures of High Plasmodium Falciparum Parasitemia in the Placenta, Volume 8. Retrieved from

Description : Plasmodium falciparum infected erythrocytes (IE) accumulate in the placenta through the interaction between Duffybinding like (DBL) domains of parasite-encoded ligand VAR2CSA and chondroitin sulphate-A (CSA) receptor. Polymorphisms in these domains, including DBL2X and DBL3X, may affect their antigenicity or CSA-binding affinity, eventually increasing parasitemia and its adverse effects on pregnancy outcomes. A total of 373 DBL2X and 328 DBL3X sequences were obtained from transcripts of 20 placental isolates infecting Mozambican women, resulting in 176 DBL2X and 191 DBL3X unique sequences at the protein level. Sequence alignments were divided in segments containing combinations of correlated polymorphisms and the association of segment sequences with placental parasite density was tested using Bonferroni corrected regression models, taking into consideration the weight of each sequence in the infection. Three DBL2X and three DBL3X segments contained signatures of high parasite density (P,0.003) that were highly prevalent in the parasite population (49–91%). Identified regions included a flexible loop that contributes to DBL3X-CSA interaction and two DBL3X motifs with evidence of positive natural selection. Limited antibody responses against signatures of high parasite density among malaria-exposed pregnant women could not explain the increased placental parasitemia. These results suggest that a higher binding efficiency to CSA rather than reduced antigenicity might provide a biological advantage to parasites with high parasite density signatures in VAR2CSA. Sequences contributing to high parasitemia may be critical for the functional characterization of VAR2CSA and the development of tools against placental malaria.


Click To View

Additional Books

  • Plos One : Deregulated Nras Expression i... (by )
  • Plos One : Tgf-β-elicited Induction of T... (by )
  • Plos One : Serologic Responses to Recomb... (by )
  • Plos One : a Cost Effectiveness and Capa... (by )
  • Plos One : Probucol Increases Striatal G... (by )
  • Plos One : Flexible Composition ; Meg Ev... (by )
  • Plos One : Exome Sequencing of Germline ... (by )
  • Plos One : a Null Relationship Between M... (by )
  • Plos One : Efficient Control of Epidemic... (by )
  • Plos One : Short-term Intensified Cycle ... (by )
  • Plos One : Line Orientation Adaptation ;... (by )
  • Plos One : the Evolutionary Paradox of T... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Fair are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.